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3NBN

Crystal structure of a dimer of Notch Transcription Complex trimers on HES1 DNA

Functional Information from GO Data
ChainGOidnamespacecontents
A0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
A0001228molecular_functionDNA-binding transcription activator activity, RNA polymerase II-specific
A0003677molecular_functionDNA binding
A0003700molecular_functionDNA-binding transcription factor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
A0006357biological_processregulation of transcription by RNA polymerase II
C0003713molecular_functiontranscription coactivator activity
C0007219biological_processNotch signaling pathway
C0007221biological_processpositive regulation of transcription of Notch receptor target
C0016607cellular_componentnuclear speck
C0045944biological_processpositive regulation of transcription by RNA polymerase II
D0000978molecular_functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
D0001228molecular_functionDNA-binding transcription activator activity, RNA polymerase II-specific
D0003677molecular_functionDNA binding
D0003700molecular_functionDNA-binding transcription factor activity
D0005634cellular_componentnucleus
D0006355biological_processregulation of DNA-templated transcription
D0006357biological_processregulation of transcription by RNA polymerase II
F0003713molecular_functiontranscription coactivator activity
F0007219biological_processNotch signaling pathway
F0007221biological_processpositive regulation of transcription of Notch receptor target
F0016607cellular_componentnuclear speck
F0045944biological_processpositive regulation of transcription by RNA polymerase II
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
CSER45
FSER45

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: (3S)-3-hydroxyasparagine; by HIF1AN => ECO:0000250
ChainResidueDetails
BASN2023
EASN2023

224201

PDB entries from 2024-08-28

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