5UXH

Structure of Human POFUT1 in complex with GDP-fucose

Summary for 5UXH

• Entry DOI: 10.2210/pdb5uxh/pdb
• Related: 5UX6
• Descriptor: GDP-fucose protein O-fucosyltransferase 1, GUANOSINE-5'-DIPHOSPHATE-BETA-L-FUCOPYRANOSE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: gdp-fucose, notch signaling, pofut1, t-all, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 85365.18

Authors

Xu, X.,McMillan, B.,Blacklow, S.C. (deposition date: 2017-02-22, release date: 2017-04-05, Last modification date: 2023-10-04)

• Primary citation: McMillan, B.J.,Zimmerman, B.,Egan, E.D.,Lofgren, M.,Xu, X.,Hesser, A.,Blacklow, S.C.; Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations.; Glycobiology, 27:777-786, 2017; PubMed: 28334865; DOI: 10.1093/glycob/cwx020

Experimental method

X-RAY DIFFRACTION (2.41 Å)