5UXH

Structure of Human POFUT1 in complex with GDP-fucose

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	GDP-fucose protein O-fucosyltransferase 1	polymer	367	41872.0	2	UniProt (Q9H488) Pfam (PF10250) In PDB	Homo sapiens (Human)	Peptide-O-fucosyltransferase 1,O-FucT-1
2	A, B	GUANOSINE-5'-DIPHOSPHATE-BETA-L-FUCOPYRANOSE	non-polymer		589.3	2	Chemie (GFB)
3	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
4		water	water		18.0	72	Chemie (HOH)

Sequence modifications

A, B: 24 - 384 (UniProt: Q9H488)

PDB	External Database	Details
Ala 160	Asn 160	engineered mutation
His 385	-	expression tag
His 386	-	expression tag
His 387	-	expression tag
His 388	-	expression tag
His 389	-	expression tag
His 390	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	83744.1
Non-Polymers*	Number of molecules	4
	Total formula weight	1621.1
All*	Total formula weight	85365.2

*Water molecules are not included.