1Q69

Solution structure of T-cell surface glycoprotein CD8 alpha chain and Proto-oncogene tyrosine-protein kinase LCK fragments

Summary for 1Q69

• Entry DOI: 10.2210/pdb1q69/pdb
• NMR Information: BMRB: 5945
• Descriptor: T-cell surface glycoprotein CD8 alpha chain, Proto-oncogene tyrosine-protein kinase LCK, ZINC ION (3 entities in total)
• Functional Keywords: peptide-peptide complex, helix-helix interaction, zinc coordination, beta hairpin, membrane protein-transferase complex, membrane protein/transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P01732; Cytoplasm: P06239
• Total number of polymer chains: 2
• Total formula weight: 5627.74

Authors

Kim, P.W.,Sun, Z.Y.,Blacklow, S.C.,Wagner, G.,Eck, M.J. (deposition date: 2003-08-12, release date: 2003-11-25, Last modification date: 2021-10-27)

• Primary citation: Kim, P.W.,Sun, Z.Y.,Blacklow, S.C.,Wagner, G.,Eck, M.J.; A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8.; Science, 301:1725-1728, 2003; PubMed: 14500983; DOI: 10.1126/science.1085643

Experimental method

SOLUTION NMR