5I6V

Structure of F285S, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2

Summary for 5I6V

• Entry DOI: 10.2210/pdb5i6v/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11, GLYCEROL (3 entities in total)
• Functional Keywords: shp2, cancer-associated mutation, inhibitors, hydrolase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q06124
• Total number of polymer chains: 2
• Total formula weight: 120559.91

Authors

Xu, X.,Blacklow, S.C. (deposition date: 2016-02-16, release date: 2016-04-13, Last modification date: 2023-09-27)

• Primary citation: LaRochelle, J.R.,Fodor, M.,Xu, X.,Durzynska, I.,Fan, L.,Stams, T.,Chan, H.M.,LaMarche, M.J.,Chopra, R.,Wang, P.,Fortin, P.D.,Acker, M.G.,Blacklow, S.C.; Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.; Biochemistry, 55:2269-2277, 2016; PubMed: 27030275; DOI: 10.1021/acs.biochem.5b01287

Experimental method

X-RAY DIFFRACTION (1.87 Å)