6CJ2

Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JWG056

Summary for 6CJ2

• Entry DOI: 10.2210/pdb6cj2/pdb
• Descriptor: Bromodomain-containing protein 4, 2-{[3-methoxy-4-(4-methylpiperazin-1-yl)phenyl]amino}-5-methyl-11-(propan-2-yl)-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one (3 entities in total)
• Functional Keywords: kinase, inhibitor, brd4, transcription, transcription-inhibitor complex, transcription/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 15298.66

Authors

Xu, X.,Blacklow, S.C. (deposition date: 2018-02-26, release date: 2019-03-06, Last modification date: 2023-10-04)

• Primary citation: Wang, J.,Erazo, T.,Ferguson, F.M.,Buckley, D.L.,Gomez, N.,Munoz-Guardiola, P.,Dieguez-Martinez, N.,Deng, X.,Hao, M.,Massefski, W.,Fedorov, O.,Offei-Addo, N.K.,Park, P.M.,Dai, L.,DiBona, A.,Becht, K.,Kim, N.D.,McKeown, M.R.,Roberts, J.M.,Zhang, J.,Sim, T.,Alessi, D.R.,Bradner, J.E.,Lizcano, J.M.,Blacklow, S.C.,Qi, J.,Xu, X.,Gray, N.S.; Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.; Acs Chem.Biol., 13:2438-2448, 2018; PubMed: 30102854; DOI: 10.1021/acschembio.7b00638

Experimental method

X-RAY DIFFRACTION (1.47 Å)