8RVE
| Vimentin intermediate filament | 分子名称: | Vimentin | 著者 | Eibauer, M, Medalia, O. | 登録日 | 2024-02-01 | 公開日 | 2024-04-10 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | 主引用文献 | Vimentin filaments integrate low-complexity domains in a complex helical structure. Nat.Struct.Mol.Biol., 31, 2024
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4AEL
| PDE10A in complex with the inhibitor AZ5 | 分子名称: | 2-(2'-ETHOXYBIPHENYL-4-YL)-4-HYDROXY-1,6-NAPHTHYRIDINE-3-CARBONITRILE, CAMP AND CAMP-INHIBITED CGMP 3', 5'-CYCLIC PHOSPHODIESTERASE 10A, ... | 著者 | Bauer, U, Giordanetto, F, Bauer, M, OMahony, G, Johansson, K.E, Knecht, W, Hartleib-Geschwindner, J, Toppner Carlsson, E, Enroth, C, Sjogren, T. | 登録日 | 2012-01-11 | 公開日 | 2012-01-25 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of 4-Hydroxy-1,6-Naphthyridine-3-Carbonitrile Derivatives as Novel Pde10A Inhibitors. Bioorg.Med.Chem.Lett., 22, 2012
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6ZLE
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7NM2
| Solution structure of MLKL executioner domain in complex with a fragment | 分子名称: | 2-[(~{S})-methoxy-(4-propan-2-ylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid, Mixed lineage kinase domain-like protein | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | 登録日 | 2021-02-23 | 公開日 | 2021-09-22 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J.Med.Chem., 64, 2021
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7NM5
| Solution structure of MLKL executioner domain in complex with a fragment | 分子名称: | 2-[(~{S})-methoxy-(4-phenylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid, Mixed lineage kinase domain-like protein | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | 登録日 | 2021-02-23 | 公開日 | 2021-09-22 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J.Med.Chem., 64, 2021
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7NM4
| Solution structure of MLKL executioner domain in complex with a fragment | 分子名称: | (~{S})-1~{H}-benzimidazol-2-yl-(4-propan-2-ylphenyl)methanol, Mixed lineage kinase domain-like protein | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | 登録日 | 2021-02-23 | 公開日 | 2021-09-22 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain. J.Med.Chem., 64, 2021
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2MBK
| The Clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed | 分子名称: | Crossveinless 2 | 著者 | Mueller, T.D, Fiebig, J.E, Weidauer, S.E, Qiu, L, Bauer, M, Schmieder, P, Beerbaum, M, Zhang, J, Oschkinat, H, Sebald, W. | 登録日 | 2013-08-02 | 公開日 | 2013-10-16 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | The Clip-Segment of the von Willebrand Domain 1 of the BMP Modulator Protein Crossveinless 2 Is Preformed. Molecules, 18, 2013
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6ZPR
| Solution structure of MLKL executioner domain in complex with a covalent inhibitor | 分子名称: | 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione, Mixed lineage kinase domain-like protein,Mixed lineage kinase domain-like protein | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | 登録日 | 2020-07-09 | 公開日 | 2020-12-16 | 最終更新日 | 2021-01-06 | 実験手法 | SOLUTION NMR | 主引用文献 | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis. Proc.Natl.Acad.Sci.USA, 117, 2020
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6ZZ1
| Crystal structure of MLKL executioner domain in complex with a covalent inhibitor | 分子名称: | 7-(2-methoxyethoxymethyl)-1,3-dimethyl-purine-2,6-dione, Mixed lineage kinase domain-like protein | 著者 | Fiegen, D, Bauer, M, Nar, H. | 登録日 | 2020-08-03 | 公開日 | 2020-12-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Locking mixed-lineage kinase domain-like protein in its auto-inhibited state prevents necroptosis. Proc.Natl.Acad.Sci.USA, 117, 2020
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6ZVO
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2YKL
| Structure of human anti-nicotine Fab fragment in complex with nicotine-11-yl-methyl-(4-ethylamino-4-oxo)-butanoate | 分子名称: | FAB FRAGMENT, HEAVY CHAIN, LIGHT CHAIN, ... | 著者 | Tars, K, Kotelovica, S, Lipowsky, G, Bauer, M, Beerli, R, Bachmann, M, Maurer, P. | 登録日 | 2011-05-27 | 公開日 | 2011-11-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Different Binding Modes of Free and Carrier-Protein-Coupled Nicotine in a Human Monoclonal Antibody. J.Mol.Biol., 415, 2012
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2YK1
| Structure of human anti-nicotine Fab fragment in complex with nicotine | 分子名称: | (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, FAB FRAGMENT, HEAVY CHAIN, ... | 著者 | Tars, K, Kotelovica, S, Lipowsky, G, Bauer, M, Beerli, R, Bachmann, M, Maurer, P. | 登録日 | 2011-05-25 | 公開日 | 2011-11-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Different Binding Modes of Free and Carrier-Protein-Coupled Nicotine in a Human Monoclonal Antibody. J.Mol.Biol., 415, 2012
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5G4N
| Crystal structure of the p53 cancer mutant Y220C in complex with a difluorinated derivative of the small molecule stabilizer Phikan083 | 分子名称: | 1-[9-(2,2-difluoroethyl)-9H-carbazol-3-yl]-N-methylmethanamine, CELLULAR TUMOR ANTIGEN P53, GLYCEROL, ... | 著者 | Joerger, A.C, Bauer, M, Jones, R.N, Spencer, J. | 登録日 | 2016-05-13 | 公開日 | 2016-06-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of P53 Mutant Y220C Rescue Drugs. Acs Chem.Biol., 11, 2016
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5G4O
| Crystal structure of the p53 cancer mutant Y220C in complex with a trifluorinated derivative of the small molecule stabilizer Phikan083 | 分子名称: | CELLULAR TUMOR ANTIGEN P53, N,N-dimethyl-1-[9-(2,2,2-trifluoroethyl)-9H-carbazol-3-yl]methanamine, ZINC ION | 著者 | Joerger, A.C, Bauer, M, Baud, M.G.J, Spencer, J. | 登録日 | 2016-05-13 | 公開日 | 2016-06-22 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of P53 Mutant Y220C Rescue Drugs. Acs Chem.Biol., 11, 2016
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5G4M
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1PFX
| PORCINE FACTOR IXA | 分子名称: | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, FACTOR IXA | 著者 | Brandstetter, H, Bauer, M, Huber, R, Lollar, P, Bode, W. | 登録日 | 1995-07-19 | 公開日 | 1996-08-17 | 最終更新日 | 2013-02-27 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | X-ray structure of clotting factor IXa: active site and module structure related to Xase activity and hemophilia B. Proc.Natl.Acad.Sci.USA, 92, 1995
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1SMP
| CRYSTAL STRUCTURE OF A COMPLEX BETWEEN SERRATIA MARCESCENS METALLO-PROTEASE AND AN INHIBITOR FROM ERWINIA CHRYSANTHEMI | 分子名称: | CALCIUM ION, ERWINIA CHRYSANTHEMI INHIBITOR, SERRATIA METALLO PROTEINASE, ... | 著者 | Baumann, U, Bauer, M, Letoffe, S, Delepelaire, P, Wandersman, C. | 登録日 | 1995-01-13 | 公開日 | 1996-04-03 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structure of a complex between Serratia marcescens metallo-protease and an inhibitor from Erwinia chrysanthemi. J.Mol.Biol., 248, 1995
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1DB2
| CRYSTAL STRUCTURE OF NATIVE PLASMINOGEN ACTIVATOR INHIBITOR-1 | 分子名称: | PLASMINOGEN ACTIVATOR INHIBITOR-1 | 著者 | Nar, H, Bauer, M, Stassen, J.M, Lang, D, Gils, A, Declerck, P. | 登録日 | 1999-11-02 | 公開日 | 1999-11-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation. J.Mol.Biol., 297, 2000
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6Z35
| De-novo Maquette 2 protein with buried ion-pair | 分子名称: | Maquette 2-1ip | 著者 | Baumgart, M, Roepke, M, Muehlbauer, M, Asami, S, Mader, S, Fredriksson, K, Groll, M, Gamiz-Hernandez, A.P, Kaila, V.R.I. | 登録日 | 2020-05-19 | 公開日 | 2021-04-07 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Design of buried charged networks in artificial proteins. Nat Commun, 12, 2021
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6EQC
| Cryo-EM reconstruction of a complex of a binding protein and human adenovirus C5 hexon | 分子名称: | Hexon protein, scFv of 9C12 antibody | 著者 | Schmid, M, Ernst, P, Honegger, A, Suomalainen, M, Zimmermann, M, Braun, L, Stauffer, S, Thom, C, Dreier, B, Eibauer, M, Kipar, A, Vogel, V, Greber, U.F, Medalia, O, Plueckthun, A. | 登録日 | 2017-10-12 | 公開日 | 2018-02-07 | 最終更新日 | 2018-02-14 | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | 主引用文献 | Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control. Nat Commun, 9, 2018
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4GH7
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5OGI
| Complex of a binding protein and human adenovirus C 5 hexon | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | 著者 | Schmid, M, Ernst, P, Honegger, A, Suomalainen, M, Zimmermann, M, Braun, L, Stauffer, S, Thom, C, Dreier, B, Eibauer, M, Kipar, A, Vogel, V, Greber, U.F, Medalia, O, Plueckthun, A. | 登録日 | 2017-07-13 | 公開日 | 2018-02-07 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Adenoviral vector with shield and adapter increases tumor specificity and escapes liver and immune control. Nat Commun, 9, 2018
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