7NJ1
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![BU of 7nj1 by Molmil](/molmil-images/mine/7nj1) | CryoEM structure of the human Separase-Securin complex | Descriptor: | Securin, Separin | Authors: | Yu, J, Raia, P, Ghent, C.M, Raisch, T, Sadian, Y, Barford, D, Raunser, S, Morgan, D.O, Boland, A. | Deposit date: | 2021-02-14 | Release date: | 2021-08-04 | Last modified: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural basis of human separase regulation by securin and CDK1-cyclin B1. Nature, 596, 2021
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7NJ0
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![BU of 7nj0 by Molmil](/molmil-images/mine/7nj0) | CryoEM structure of the human Separase-Cdk1-cyclin B1-Cks1 complex | Descriptor: | Cyclin-dependent kinase 1, Cyclin-dependent kinases regulatory subunit 1, G2/mitotic-specific cyclin-B1,G2/mitotic-specific cyclin-B1, ... | Authors: | Yu, J, Raia, P, Ghent, C.M, Raisch, T, Sadian, Y, Barford, D, Raunser, S, Morgan, D.O, Boland, A. | Deposit date: | 2021-02-14 | Release date: | 2021-08-04 | Last modified: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structural basis of human separase regulation by securin and CDK1-cyclin B1. Nature, 596, 2021
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7ON1
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![BU of 7on1 by Molmil](/molmil-images/mine/7on1) | Cenp-A nucleosome in complex with Cenp-C | Descriptor: | BJ4_G0006610.mRNA.1.CDS.1, BJ4_G0007000.mRNA.1.CDS.1, DNA (123-MER), ... | Authors: | Yan, K, Yang, J, Zhang, Z, Barford, D. | Deposit date: | 2021-05-25 | Release date: | 2021-07-07 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.35 Å) | Cite: | Cenp-A nucleosome in complex with Cenp-C To Be Published
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8QV3
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![BU of 8qv3 by Molmil](/molmil-images/mine/8qv3) | Structure of the y-Tubulin Small Complex (yTuSC) as part of the native y-Tubulin Ring Complex (yTuRC) capping microtubule minus ends at the spindle pole body | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, Spindle pole body component, Spindle pole body component 110, ... | Authors: | Dendooven, T, Yatskevich, S, Burt, A, Bellini, D, Kilmartin, J, Barford, D. | Deposit date: | 2023-10-17 | Release date: | 2024-04-24 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (8.2 Å) | Cite: | Structure of the native gamma-tubulin ring complex capping spindle microtubules. Nat.Struct.Mol.Biol., 31, 2024
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8QV2
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![BU of 8qv2 by Molmil](/molmil-images/mine/8qv2) | Structure of the native y-Tubulin Ring Complex (yTuRC) capping microtubule minus ends at the spindle pole body | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Spindle pole body component, ... | Authors: | Dendooven, T, Yatskevich, S, Burt, A, Bellini, D, Kilmartin, J, Barford, D. | Deposit date: | 2023-10-17 | Release date: | 2024-04-24 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (9.2 Å) | Cite: | Structure of the native gamma-tubulin ring complex capping spindle microtubules. Nat.Struct.Mol.Biol., 31, 2024
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8QV0
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![BU of 8qv0 by Molmil](/molmil-images/mine/8qv0) | Structure of the native microtubule lattice nucleated from the yeast spindle pole body | Descriptor: | Tubulin alpha-1 chain, Tubulin beta chain | Authors: | Dendooven, T, Yatskevich, S, Burt, A, Bellini, D, Kilmartin, J, Barford, D. | Deposit date: | 2023-10-17 | Release date: | 2024-04-24 | Last modified: | 2024-07-31 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Structure of the native gamma-tubulin ring complex capping spindle microtubules. Nat.Struct.Mol.Biol., 31, 2024
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8PPR
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![BU of 8ppr by Molmil](/molmil-images/mine/8ppr) | |
3ZJE
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![BU of 3zje by Molmil](/molmil-images/mine/3zje) | A20 OTU domain in reversibly oxidised (SOH) state | Descriptor: | 1,2-ETHANEDIOL, A20P50, CHLORIDE ION | Authors: | Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D. | Deposit date: | 2013-01-17 | Release date: | 2013-03-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation Nat.Commun., 4, 2013
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3ZJG
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![BU of 3zjg by Molmil](/molmil-images/mine/3zjg) | A20 OTU domain with irreversibly oxidised Cys103 from 60 min H2O2 soak. | Descriptor: | CHLORIDE ION, TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3 | Authors: | Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D. | Deposit date: | 2013-01-17 | Release date: | 2013-03-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation Nat.Commun., 4, 2013
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3ZJD
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![BU of 3zjd by Molmil](/molmil-images/mine/3zjd) | A20 OTU domain in reduced, active state at 1.87 A resolution | Descriptor: | 1,2-ETHANEDIOL, A20P50, CHLORIDE ION | Authors: | Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D. | Deposit date: | 2013-01-17 | Release date: | 2013-03-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation Nat.Commun., 4, 2013
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3ZJF
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![BU of 3zjf by Molmil](/molmil-images/mine/3zjf) | A20 OTU domain with irreversibly oxidised Cys103 from 270 min H2O2 soak. | Descriptor: | A20P50, CHLORIDE ION | Authors: | Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D. | Deposit date: | 2013-01-17 | Release date: | 2013-03-06 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation Nat.Commun., 4, 2013
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4ADY
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![BU of 4ady by Molmil](/molmil-images/mine/4ady) | Crystal structure of 26S proteasome subunit Rpn2 | Descriptor: | 26S PROTEASOME REGULATORY SUBUNIT RPN2 | Authors: | Kulkarni, K, He, J, Da Fonseca, P.C.A, Krutauz, D, Glickman, M.H, Barford, D, Morris, E.P. | Deposit date: | 2012-01-04 | Release date: | 2012-03-14 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Structure of the 26S Proteasome Subunit Rpn2 Reveals its Pc Repeat Domain as a Closed Toroid of Two Concentric Alpha-Helical Rings Structure, 20, 2012
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1B3U
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![BU of 1b3u by Molmil](/molmil-images/mine/1b3u) | CRYSTAL STRUCTURE OF CONSTANT REGULATORY DOMAIN OF HUMAN PP2A, PR65ALPHA | Descriptor: | PROTEIN (PROTEIN PHOSPHATASE PP2A) | Authors: | Groves, M.R, Hanlon, N, Turowski, P, Hemmings, B, Barford, D. | Deposit date: | 1998-12-14 | Release date: | 1999-04-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs. Cell(Cambridge,Mass.), 96, 1999
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1A17
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![BU of 1a17 by Molmil](/molmil-images/mine/1a17) | TETRATRICOPEPTIDE REPEATS OF PROTEIN PHOSPHATASE 5 | Descriptor: | SERINE/THREONINE PROTEIN PHOSPHATASE 5, SULFATE ION | Authors: | Das, A.K, Cohen, P.T.W, Barford, D. | Deposit date: | 1997-12-23 | Release date: | 1998-04-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions. EMBO J., 17, 1998
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1A6Q
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![BU of 1a6q by Molmil](/molmil-images/mine/1a6q) | CRYSTAL STRUCTURE OF THE PROTEIN SERINE/THREONINE PHOSPHATASE 2C AT 2 A RESOLUTION | Descriptor: | MANGANESE (II) ION, PHOSPHATASE 2C, PHOSPHATE ION | Authors: | Das, A.K, Helps, N.R, Cohen, P.T.W, Barford, D. | Deposit date: | 1998-02-27 | Release date: | 1998-05-27 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution. EMBO J., 15, 1996
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6TGB
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![BU of 6tgb by Molmil](/molmil-images/mine/6tgb) | CryoEM structure of the binary DOCK2-ELMO1 complex | Descriptor: | Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1 | Authors: | Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D. | Deposit date: | 2019-11-15 | Release date: | 2020-07-29 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state. Nat Commun, 11, 2020
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8QRY
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![BU of 8qry by Molmil](/molmil-images/mine/8qry) | |
6TGC
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![BU of 6tgc by Molmil](/molmil-images/mine/6tgc) | CryoEM structure of the ternary DOCK2-ELMO1-RAC1 complex. | Descriptor: | Dedicator of cytokinesis protein 2, Engulfment and cell motility protein 1, Ras-related C3 botulinum toxin substrate 1 | Authors: | Chang, L, Yang, J, Chang, J.H, Zhang, Z, Boland, A, McLaughlin, S.H, Abu-Thuraia, A, Killoran, R.C, Smith, M.J, Cote, J.F, Barford, D. | Deposit date: | 2019-11-15 | Release date: | 2020-07-29 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structure of the DOCK2-ELMO1 complex provides insights into regulation of the auto-inhibited state. Nat Commun, 11, 2020
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8OVW
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![BU of 8ovw by Molmil](/molmil-images/mine/8ovw) | Cryo-EM structure of CBF1-CCAN bound topologically to centromeric DNA | Descriptor: | C0N3 DNA, Centromere-binding protein 1, Inner kinetochore subunit AME1, ... | Authors: | Dendooven, T.D, Zhang, Z, Yang, J, McLaughlin, S, Schwabb, J, Scheres, S, Yatskevich, S, Barford, D. | Deposit date: | 2023-04-26 | Release date: | 2023-08-09 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere. Sci Adv, 9, 2023
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8OW0
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![BU of 8ow0 by Molmil](/molmil-images/mine/8ow0) | Cryo-EM structure of CBF1-CCAN bound topologically to a centromeric CENP-A nucleosome | Descriptor: | C0N3 DNA, Centromere-binding protein 1, Histone H2A.1, ... | Authors: | Dendooven, T.D, Zhang, Z, Yang, J, McLaughlin, S, Schwabb, J, Scheres, S, Yatskevich, S, Barford, D. | Deposit date: | 2023-04-26 | Release date: | 2023-08-09 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere. Sci Adv, 9, 2023
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8OW1
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![BU of 8ow1 by Molmil](/molmil-images/mine/8ow1) | Cryo-EM structure of the yeast Inner kinetochore bound to a CENP-A nucleosome. | Descriptor: | C0N3, Centromere DNA-binding protein complex CBF3 subunit B, Centromere DNA-binding protein complex CBF3 subunit C, ... | Authors: | Dendooven, T.D, Zhang, Z, Yang, J, McLaughlin, S, Schwabb, J, Scheres, S, Yatskevich, S, Barford, D. | Deposit date: | 2023-04-26 | Release date: | 2023-08-09 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere. Sci Adv, 9, 2023
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8PKP
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![BU of 8pkp by Molmil](/molmil-images/mine/8pkp) | Cryo-EM structure of the apo Anaphase-promoting complex/cyclosome (APC/C) at 3.2 Angstrom resolution | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | Authors: | Hoefler, A, Yu, J, Chang, L, Zhang, Z, Yang, J, Boland, A, Barford, D. | Deposit date: | 2023-06-27 | Release date: | 2023-07-19 | Last modified: | 2024-08-07 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | High-resolution structure of the Anaphase-promoting complex (APC/C) bound to co-activator Cdh1 To Be Published
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8Q85
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![BU of 8q85 by Molmil](/molmil-images/mine/8q85) | |
8Q84
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![BU of 8q84 by Molmil](/molmil-images/mine/8q84) | |
8QAU
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![BU of 8qau by Molmil](/molmil-images/mine/8qau) | Outer kinetochore Ndc80-Dam1 alpha/beta-tubulin complex | Descriptor: | DASH complex subunit DAM1, GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Muir, K.W, Barford, D. | Deposit date: | 2023-08-23 | Release date: | 2024-04-03 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Mechanism of outer kinetochore assembly on microtubules and its regulation by mitotic error correction Biorxiv, 2023
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