7NJ1

CryoEM structure of the human Separase-Securin complex

Summary for 7NJ1

• Entry DOI: 10.2210/pdb7nj1/pdb
• EMDB information: 12369
• Descriptor: Separin, Securin (2 entities in total)
• Functional Keywords: pseudosubstrate heat repeat caspase cell cycle, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 259662.81

Authors

Yu, J.,Raia, P.,Ghent, C.M.,Raisch, T.,Sadian, Y.,Barford, D.,Raunser, S.,Morgan, D.O.,Boland, A. (deposition date: 2021-02-14, release date: 2021-08-04, Last modification date: 2021-08-18)

• Primary citation: Yu, J.,Raia, P.,Ghent, C.M.,Raisch, T.,Sadian, Y.,Cavadini, S.,Sabale, P.M.,Barford, D.,Raunser, S.,Morgan, D.O.,Boland, A.; Structural basis of human separase regulation by securin and CDK1-cyclin B1.; Nature, 596:138-142, 2021; PubMed: 34290405; DOI: 10.1038/s41586-021-03764-0

Experimental method

ELECTRON MICROSCOPY (2.9 Å)