7NJ1

CryoEM structure of the human Separase-Securin complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000070	biological_process	mitotic sister chromatid segregation
A	0000280	biological_process	nuclear division
A	0000281	biological_process	mitotic cytokinesis
A	0003824	molecular_function	catalytic activity
A	0004197	molecular_function	cysteine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005829	cellular_component	cytosol
A	0006508	biological_process	proteolysis
A	0006915	biological_process	apoptotic process
A	0007059	biological_process	chromosome segregation
A	0008233	molecular_function	peptidase activity
A	0008234	molecular_function	cysteine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0040001	biological_process	establishment of mitotic spindle localization
A	0045842	biological_process	positive regulation of mitotic metaphase/anaphase transition
A	0045875	biological_process	negative regulation of sister chromatid cohesion
A	0051306	biological_process	mitotic sister chromatid separation
A	0051307	biological_process	meiotic chromosome separation
A	0072686	cellular_component	mitotic spindle
A	0098813	biological_process	nuclear chromosome segregation
B	0004869	molecular_function	cysteine-type endopeptidase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006974	biological_process	DNA damage response
B	0007059	biological_process	chromosome segregation
B	0007283	biological_process	spermatogenesis
B	0017124	molecular_function	SH3 domain binding
B	0045143	biological_process	homologous chromosome segregation
B	0051276	biological_process	chromosome organization
B	0051301	biological_process	cell division
B	0140677	molecular_function	molecular function activator activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	95
Details	Domain: {"description":"Peptidase C50"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {}

Chain

Residue

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by CDK1","evidences":[{"source":"PubMed","id":"10656688","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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