7NJ1
CryoEM structure of the human Separase-Securin complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Separin | polymer | 2160 | 237610.5 | 1 | UniProt (Q14674) Pfam (PF03568) In PDB | Homo sapiens (Human) | Caspase-like protein ESPL1,Extra spindle poles-like 1 protein,Separase |
2 | B | Securin | polymer | 202 | 22052.3 | 1 | UniProt (O95997) Pfam (PF04856) In PDB | Homo sapiens (Human) | Esp1-associated protein,Pituitary tumor-transforming gene 1 protein,Tumor-transforming protein 1,hPTTG |
Sequence modifications
A: 1 - 2120 (UniProt: Q14674)
PDB | External Database | Details |
---|---|---|
Asp 25 | Ala 25 | conflict |
Val 116 | Ala 116 | conflict |
Ile 693 | Met 693 | conflict |
Ser 1329 | Arg 1329 | conflict |
Gln 1561 | Arg 1561 | conflict |
His 2037 | Arg 2037 | conflict |
Ser 2121 | - | expression tag |
Ser 2122 | - | expression tag |
Leu 2123 | - | expression tag |
Ala 2124 | - | expression tag |
Glu 2125 | - | expression tag |
Glu 2126 | - | expression tag |
Asn 2127 | - | expression tag |
Leu 2128 | - | expression tag |
Tyr 2129 | - | expression tag |
Phe 2130 | - | expression tag |
Gln 2131 | - | expression tag |
Ser 2132 | - | expression tag |
Trp 2133 | - | expression tag |
Ser 2134 | - | expression tag |
His 2135 | - | expression tag |
Pro 2136 | - | expression tag |
Gln 2137 | - | expression tag |
Phe 2138 | - | expression tag |
Glu 2139 | - | expression tag |
Lys 2140 | - | expression tag |
Gly 2141 | - | expression tag |
Gly 2142 | - | expression tag |
Gly 2143 | - | expression tag |
Ser 2144 | - | expression tag |
Gly 2145 | - | expression tag |
Gly 2146 | - | expression tag |
Gly 2147 | - | expression tag |
Ser 2148 | - | expression tag |
Gly 2149 | - | expression tag |
Gly 2150 | - | expression tag |
Gly 2151 | - | expression tag |
Ser 2152 | - | expression tag |
Trp 2153 | - | expression tag |
Ser 2154 | - | expression tag |
His 2155 | - | expression tag |
Pro 2156 | - | expression tag |
Gln 2157 | - | expression tag |
Phe 2158 | - | expression tag |
Glu 2159 | - | expression tag |
Lys 2160 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 259662.8 | |
All* | Total formula weight | 259662.8 |