2J25
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![BU of 2j25 by Molmil](/molmil-images/mine/2j25) | Partially deglycosylated glucoceramidase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLUCOSYLCERAMIDASE, ... | 著者 | Brumshtein, B, Wormald, M.R, Silman, I, Futerman, A.H, Sussman, J.L. | 登録日 | 2006-08-16 | 公開日 | 2006-12-06 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural Comparison of Differently Glycosylated Forms of Acid-Beta-Glucosidase, the Defective Enzyme in Gaucher Disease Acta Crystallogr.,Sect.D, 62, 2006
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3EBH
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![BU of 3ebh by Molmil](/molmil-images/mine/3ebh) | Structure of the M1 Alanylaminopeptidase from malaria complexed with bestatin | 分子名称: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, GLYCEROL, M1 family aminopeptidase, ... | 著者 | McGowan, S, Porter, C.J, Buckle, A.M, Whisstock, J.C. | 登録日 | 2008-08-27 | 公開日 | 2009-01-27 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase Proc.Natl.Acad.Sci.USA, 106, 2009
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5KDD
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![BU of 5kdd by Molmil](/molmil-images/mine/5kdd) | Apo-structure of humanised RadA-mutant humRadA22 | 分子名称: | DNA repair and recombination protein RadA, SULFATE ION | 著者 | Fischer, G, Marsh, M, Moschetti, T, Sharpe, T, Scott, D, Morgan, M, Ng, H, Skidmore, J, Venkitaraman, A, Abell, C, Blundell, T.L, Hyvonen, M. | 登録日 | 2016-06-08 | 公開日 | 2016-10-19 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Engineering Archeal Surrogate Systems for the Development of Protein-Protein Interaction Inhibitors against Human RAD51. J.Mol.Biol., 428, 2016
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6PQO
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![BU of 6pqo by Molmil](/molmil-images/mine/6pqo) | Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010 | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide, ... | 著者 | Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y. | 登録日 | 2019-07-09 | 公開日 | 2020-01-08 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel. Neuron, 105, 2020
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6W9T
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2IDM
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![BU of 2idm by Molmil](/molmil-images/mine/2idm) | 2.00 A Structure of T87I/Y106W Phosphono-CheY | 分子名称: | ACETATE ION, Chemotaxis protein cheY | 著者 | Halkides, C.J, Haas, R.M, McAdams, K.A, Casper, E.S, Santarsiero, B.D, Mesecar, A.D. | 登録日 | 2006-09-15 | 公開日 | 2007-09-25 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The structures of T87I phosphono-CheY and T87I/Y106W phosphono-CheY help to explain their binding affinities to the FliM and CheZ peptides. Arch.Biochem.Biophys., 479, 2008
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7TBH
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![BU of 7tbh by Molmil](/molmil-images/mine/7tbh) | cryo-EM structure of MBP-KIX-apoferritin complex with peptide 7 | 分子名称: | Isoform 2 of CREB-binding protein,Ferritin heavy chain, N-terminally processed, LEU-SER-ARG-ARG-PRO-SEP-TYR-ARG-LYS-ILE-LEU-ASN-ASP-LEU-SER-SER-ASP-ALA-PRO | 著者 | Zhang, K, Horikoshi, N, Li, S, Powers, A, Hameedi, M, Pintilie, G, Chae, H, Khan, Y, Suomivuori, C, Dror, R, Sakamoto, K, Chiu, W, Wakatsuki, S. | 登録日 | 2021-12-22 | 公開日 | 2022-03-16 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Cryo-EM, Protein Engineering, and Simulation Enable the Development of Peptide Therapeutics against Acute Myeloid Leukemia. Acs Cent.Sci., 8, 2022
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1JWM
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![BU of 1jwm by Molmil](/molmil-images/mine/1jwm) | Crystal Structure of the Complex of the MHC Class II Molecule HLA-DR1(HA peptide 306-318) with the Superantigen SEC3 | 分子名称: | Enterotoxin type C-3, HA peptide, HLA class II histocompatibility antigen, ... | 著者 | Sundberg, E.J, Andersen, P.S, Schlievert, P.M, Karjalainen, K, Mariuzza, R.A. | 登録日 | 2001-09-04 | 公開日 | 2003-07-08 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural, energetic, and functional analysis of a protein-protein interface at distinct stages of affinity
maturation Structure, 11, 2003
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5KCO
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![BU of 5kco by Molmil](/molmil-images/mine/5kco) | SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy | 分子名称: | DIMETHYL SULFOXIDE, Histone-lysine N-methyltransferase SETDB1, SULFATE ION, ... | 著者 | Tempel, W, Harding, R.J, Mader, P, Dobrovetsky, E, Walker, J.R, Brown, P.J, Schapira, M, Collins, P, Pearce, N, Brandao-Neto, J, Douangamath, A, von Delft, F, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Santhakumar, V, Structural Genomics Consortium (SGC) | 登録日 | 2016-06-06 | 公開日 | 2016-07-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | SETDB1 in complex with an early stage, low affinity fragment candidate modelled at reduced occupancy To Be Published
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3EKL
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![BU of 3ekl by Molmil](/molmil-images/mine/3ekl) | Structural Characterization of tetrameric Mycobacterium tuberculosis fructose 1,6-bisphosphate aldolase - substrate binding and catalysis mechanism of a class IIa bacterial aldolase | 分子名称: | 1,3-DIHYDROXYACETONEPHOSPHATE, Fructose-bisphosphate aldolase, SODIUM ION, ... | 著者 | Pegan, S, Rukseree, K, Franzblau, S.G, Mesecar, A.D. | 登録日 | 2008-09-19 | 公開日 | 2009-02-10 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Structural basis for catalysis of a tetrameric class IIa fructose 1,6-bisphosphate aldolase from Mycobacterium tuberculosis J.Mol.Biol., 386, 2009
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7SN9
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5KDI
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![BU of 5kdi by Molmil](/molmil-images/mine/5kdi) | How FAPP2 Selects Simple Glycosphingolipids Using the GLTP-fold | 分子名称: | (~{Z})-~{N}-[(~{E},2~{S},3~{R})-1-[(2~{R},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-octadec-4-en-2-yl]octadec-9-enamide, Pleckstrin homology domain-containing family A member 8 | 著者 | Ochoa-Lizarralde, B, Popov, A.N, Samygina, V.R, Patel, D.J, Brown, R.E, Malinina, L. | 登録日 | 2016-06-08 | 公開日 | 2017-12-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural analyses of 4-phosphate adaptor protein 2 yield mechanistic insights into sphingolipid recognition by the glycolipid transfer protein family. J.Biol.Chem., 293, 2018
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2J4E
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![BU of 2j4e by Molmil](/molmil-images/mine/2j4e) | THE ITP COMPLEX OF HUMAN INOSINE TRIPHOSPHATASE | 分子名称: | INOSINE 5'-TRIPHOSPHATE, INOSINE TRIPHOSPHATE PYROPHOSPHATASE, INOSINIC ACID, ... | 著者 | Stenmark, P, Kursula, P, Arrowsmith, C, Berglund, H, Busam, R, Collins, R, Edwards, A, Ehn, M, Flodin, S, Flores, A, Graslund, S, Hammarstrom, M, Hallberg, B.M, Holmbergschiavone, L, Hogbom, M, Kotenyova, T, Landry, R, Loppnau, P, Magnusdottir, A, Nilsson-Ehle, P, Nyman, T, Ogg, D, Persson, C, Sagemark, J, Sundstrom, M, Uppenberg, J, Thorsell, A.G, Schuler, H, Van Den Berg, S, Wallden, K, Weigelt, J, Nordlund, P. | 登録日 | 2006-08-29 | 公開日 | 2006-09-20 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure of Human Inosine Triphosphatase: Substrate Binding and Implication of the Inosine Triphosphatase Deficiency Mutation P32T. J.Biol.Chem., 282, 2007
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4RF0
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![BU of 4rf0 by Molmil](/molmil-images/mine/4rf0) | Crystal structure of the Middle-East respiratory syndrome coronavirus papain-like protease in complex with ubiquitin (space group P6522) | 分子名称: | 3-AMINOPROPANE, ORF1ab protein, SULFATE ION, ... | 著者 | Bailey-Elkin, B.A, Johnson, G.G, Mark, B.L. | 登録日 | 2014-09-24 | 公開日 | 2014-10-22 | 最終更新日 | 2015-01-14 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression. J.Biol.Chem., 289, 2014
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2IJ5
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6PQK
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6VR7
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![BU of 6vr7 by Molmil](/molmil-images/mine/6vr7) | Structure of a pseudomurein peptide ligase type C from Methanothermus fervidus | 分子名称: | ACETOACETIC ACID, GLYCEROL, Mur ligase middle domain protein, ... | 著者 | Carbone, V, Schofield, L.R, Sutherland-Smith, A.J, Ronimus, R.S, Subedi, B.P. | 登録日 | 2020-02-06 | 公開日 | 2021-02-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Archaeal pseudomurein and bacterial murein cell wall biosynthesis share a common evolutionary ancestry FEMS Microbes, 2, 2021
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6I1B
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4QXI
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![BU of 4qxi by Molmil](/molmil-images/mine/4qxi) | Crystal structure of human AR complexed with NADP+ and AK198 | 分子名称: | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {2-[(4-amino-2-fluorobenzyl)carbamoyl]-5-chlorophenoxy}acetic acid | 著者 | Cousido-Siah, A, Mitschler, A, Ruiz, F.X, Fanfrlik, J, Hobza, P, Podjarny, A.D. | 登録日 | 2014-07-21 | 公開日 | 2015-07-22 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (0.867 Å) | 主引用文献 | The Effect of Halogen-to-Hydrogen Bond Substitution on Human Aldose Reductase Inhibition. Acs Chem.Biol., 10, 2015
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6VQS
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3EU4
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![BU of 3eu4 by Molmil](/molmil-images/mine/3eu4) | Crystal Structure of BdbD from Bacillus subtilis (oxidised) | 分子名称: | BdbD, CALCIUM ION | 著者 | Crow, A, Moller, M.C, Hederstedt, L, Le Brun, N. | 登録日 | 2008-10-09 | 公開日 | 2009-06-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal Structure and Biophysical Properties of Bacillus subtilis BdbD: AN OXIDIZING THIOL:DISULFIDE OXIDOREDUCTASE CONTAINING A NOVEL METAL SITE J.Biol.Chem., 284, 2009
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4V2C
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![BU of 4v2c by Molmil](/molmil-images/mine/4v2c) | mouse FLRT2 LRR domain in complex with rat Unc5D Ig1 domain | 分子名称: | FIBRONECTIN LEUCINE RICH TRANSMEMBRANE PROTEIN 2, PROTEIN UNC5D | 著者 | Seiradake, E, del Toro, D, Nagel, D, Cop, F, Haertl, R, Ruff, T, Seyit-Bremer, G, Harlos, K, Border, E.C, Acker-Palmer, A, Jones, E.Y, Klein, R. | 登録日 | 2014-10-08 | 公開日 | 2014-11-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (4 Å) | 主引用文献 | Flrt Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development Neuron, 84, 2014
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3E4D
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![BU of 3e4d by Molmil](/molmil-images/mine/3e4d) | Structural and Kinetic Study of an S-Formylglutathione Hydrolase from Agrobacterium tumefaciens | 分子名称: | CHLORIDE ION, Esterase D, MAGNESIUM ION | 著者 | Van Straaten, K.E, Gonzalez, C.F, Valladares, R.B, Xu, X, Savchenko, A.V, Sanders, D.A.R. | 登録日 | 2008-08-11 | 公開日 | 2009-08-18 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | The structure of a putative S-formylglutathione hydrolase from Agrobacterium tumefaciens Protein Sci., 18, 2009
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5KGR
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![BU of 5kgr by Molmil](/molmil-images/mine/5kgr) | Spin-Labeled T4 Lysozyme Construct I9V1/V131V1 (30 days) | 分子名称: | CHLORIDE ION, Endolysin, HEXANE-1,6-DIOL, ... | 著者 | Balo, A.R, Feyrer, H, Ernst, O.P. | 登録日 | 2016-06-13 | 公開日 | 2017-02-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.473 Å) | 主引用文献 | Toward Precise Interpretation of DEER-Based Distance Distributions: Insights from Structural Characterization of V1 Spin-Labeled Side Chains. Biochemistry, 55, 2016
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4RDW
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![BU of 4rdw by Molmil](/molmil-images/mine/4rdw) | The structure of N-formimino-L-Glutamate Iminohydrolase from Pseudomonas aeruginosa complexed with N-Guanidino-L-Glutaric acid | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Fedorov, A.A, Fedorov, E.V, Marti-Arbona, R, Raushel, F.M, Almo, S.C. | 登録日 | 2014-09-19 | 公開日 | 2014-10-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.591 Å) | 主引用文献 | The structure of N-formimino-L-Glutamate Iminohydrolase from Pseudomonas aeruginosa complexed with N-Guanidino-L-Glutaric acid To be Published
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