6W9T

Crystal structure of Neisseria meningitidis ClpP protease complex with small molecule activator ACP1-06

Summary for 6W9T

• Entry DOI: 10.2210/pdb6w9t/pdb
• Descriptor: ATP-dependent Clp protease proteolytic subunit, POTASSIUM ION, N-{2-[(2-chlorophenyl)sulfanyl]ethyl}-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}propanamide, ... (4 entities in total)
• Functional Keywords: serine protease, proteostasis, activator, complex, antibacterial drugs, hydrolase
• Biological source: Neisseria meningitidis
• Total number of polymer chains: 7
• Total formula weight: 155687.88

Authors

Mabanglo, M.F.,Houry, W.A. (deposition date: 2020-03-23, release date: 2020-12-09, Last modification date: 2023-10-18)

• Primary citation: Binepal, G.,Mabanglo, M.F.,Goodreid, J.D.,Leung, E.,Barghash, M.M.,Wong, K.S.,Lin, F.,Cossette, M.,Bansagi, J.,Song, B.,Balasco Serrao, V.H.,Pai, E.F.,Batey, R.A.,Gray-Owen, S.D.,Houry, W.A.; Development of Antibiotics That Dysregulate the Neisserial ClpP Protease.; Acs Infect Dis., 6:3224-3236, 2020; PubMed: 33237740; DOI: 10.1021/acsinfecdis.0c00599

Experimental method

X-RAY DIFFRACTION (1.64 Å)