2J25

Partially deglycosylated glucoceramidase

Summary for 2J25

Entry DOI	10.2210/pdb2j25/pdb
Related	1OGS 1Y7V 2F61
Descriptor	GLUCOSYLCERAMIDASE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	pharmaceutical, gaucher disease, disease mutation, glycosidase, sphingolipid, polymorphism, glycoprotein, membrane, lysosome, hydrolase, glucosidase, glucocerebrosidase, alternative initiation, lipid metabolism, cerezyme hydrolase, sphingolipid metabolism
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	115480.78
Authors	Brumshtein, B.,Wormald, M.R.,Silman, I.,Futerman, A.H.,Sussman, J.L. (deposition date: 2006-08-16, release date: 2006-12-06, Last modification date: 2023-12-13)
Primary citation	Brumshtein, B.,Wormald, M.R.,Silman, I.,Futerman, A.H.,Sussman, J.L. Structural Comparison of Differently Glycosylated Forms of Acid-Beta-Glucosidase, the Defective Enzyme in Gaucher Disease Acta Crystallogr.,Sect.D, 62:1458-, 2006 Cited by PubMed: 17139081 DOI: 10.1107/S0907444906038303 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation