1Y7V
X-ray structure of human acid-beta-glucosidase covalently bound to conduritol B epoxide
Summary for 1Y7V
Entry DOI | 10.2210/pdb1y7v/pdb |
Related | 1OGS |
Descriptor | Glucosylceramidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (5 entities in total) |
Functional Keywords | gaucher disease, glucosidase, glucocerebrosidase, cerezyme, hydrolase, glycosidase, sphingolipid metabolism, glycoprotein, lysosome, membrane, disease mutation, alternative initiation, israel structural proteomics center, ispc, structural genomics |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 113738.27 |
Authors | Premkumar, L.,Sawkar, A.R.,Boldin-Adamsky, S.,Toker, L.,Silman, I.,Kelly, J.W.,Futerman, A.H.,Sussman, J.L.,Israel Structural Proteomics Center (ISPC) (deposition date: 2004-12-10, release date: 2005-04-12, Last modification date: 2023-08-23) |
Primary citation | Premkumar, L.,Sawkar, A.R.,Boldin-Adamsky, S.,Toker, L.,Silman, I.,Kelly, J.W.,Futerman, A.H.,Sussman, J.L. X-ray structure of human acid-beta-glucosidase covalently bound to conduritol-B-epoxide. Implications for Gaucher disease. J.Biol.Chem., 280:23815-23819, 2005 Cited by PubMed: 15817452DOI: 10.1074/jbc.M502799200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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