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1Y7V

X-ray structure of human acid-beta-glucosidase covalently bound to conduritol B epoxide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Glucosylceramidasepolymer49755640.22UniProt (P04062)
Pfam (PF02055)
Pfam (PF17189)
Homo sapiens (human)Beta-glucocerebrosidase, Acid beta-glucosidase, D-glucosyl-N-acylsphingosine glucohydrolase, Alglucerase, Imiglucerase
2C, D
(C, D)
2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.42In PDB
GlyTouCan (G42666HT)
3E, F, G, H, I...
(A, B)
SULFATE IONnon-polymer96.113Chemie (SO4)
4L, S
(A, B)
1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANEnon-polymer180.22Chemie (INS)
5T, U
(A, B)
waterwater18.0286Chemie (HOH)
Sequence modifications
A, B: 1 - 497 (UniProt: P04062)
PDBExternal DatabaseDetails
His 495Arg 534engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight111280.3
BranchedNumber of molecules2
Total formula weight848.8
Non-Polymers*Number of molecules15
Total formula weight1609.1
All*Total formula weight113738.3
*Water molecules are not included.

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PDB entries from 2025-07-23

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