5KDI

How FAPP2 Selects Simple Glycosphingolipids Using the GLTP-fold

Summary for 5KDI

Entry DOI	10.2210/pdb5kdi/pdb
Descriptor	Pleckstrin homology domain-containing family A member 8, (~{Z})-~{N}-[(~{E},2~{S},3~{R})-1-[(2~{R},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-octadec-4-en-2-yl]octadec-9-enamide (3 entities in total)
Functional Keywords	gltp-fold, lipid transfer, lipid transport
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	48430.20
Authors	Ochoa-Lizarralde, B.,Popov, A.N.,Samygina, V.R.,Patel, D.J.,Brown, R.E.,Malinina, L. (deposition date: 2016-06-08, release date: 2017-12-13, Last modification date: 2023-09-27)
Primary citation	Ochoa-Lizarralde, B.,Gao, Y.G.,Popov, A.N.,Samygina, V.R.,Zhai, X.,Mishra, S.K.,Boldyrev, I.A.,Molotkovsky, J.G.,Simanshu, D.K.,Patel, D.J.,Brown, R.E.,Malinina, L. Structural analyses of 4-phosphate adaptor protein 2 yield mechanistic insights into sphingolipid recognition by the glycolipid transfer protein family. J.Biol.Chem., 293:16709-16723, 2018 Cited by PubMed: 30206120 DOI: 10.1074/jbc.RA117.000733 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.45 Å)

Structure validation