5KDI
How FAPP2 Selects Simple Glycosphingolipids Using the GLTP-fold
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Pleckstrin homology domain-containing family A member 8 | polymer | 211 | 23489.0 | 2 | UniProt (Q96JA3) Pfam (PF08718) | Homo sapiens (Human) | PH domain-containing family A member 8,Phosphatidylinositol-four-phosphate adapter protein 2,hFAPP2,Serologically defined breast cancer antigen NY-BR-86, FAPP2-GLTPH domain |
| 2 | C, D (A, B) | (~{Z})-~{N}-[(~{E},2~{S},3~{R})-1-[(2~{R},3~{R},4~{S},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-octadec-4-en-2-yl]octadec-9-enamide | non-polymer | 726.1 | 2 | Chemie (6S8) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 493 | Chemie (HOH) |
Sequence modifications
A, B: 309 - 519 (UniProt: Q96JA3)
| PDB | External Database | Details |
|---|---|---|
| Ala 377 | Glu 377 | engineered mutation |
| Lys 378 | Glu 378 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46978.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1452.2 | |
| All* | Total formula weight | 48430.2 |
