6KIX
 
 | | Cryo-EM structure of human MLL1-NCP complex, binding mode1 | | 分子名称: | DNA (145-MER), GLUTAMINE, Histone H2A, ... | | 著者 | Huang, J, Xue, H, Yao, T. | | 登録日 | 2019-07-20 | | 公開日 | 2019-09-11 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
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6KIV
 | | Cryo-EM structure of human MLL1-ubNCP complex (4.0 angstrom) | | 分子名称: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | | 著者 | Huang, J, Xue, H, Yao, T. | | 登録日 | 2019-07-20 | | 公開日 | 2019-09-11 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
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6KIZ
 | | Cryo-EM structure of human MLL1-NCP complex, binding mode2 | | 分子名称: | DNA (145-MER), Histone H2A, Histone H2B 1.1, ... | | 著者 | Huang, J, Xue, H, Yao, T. | | 登録日 | 2019-07-20 | | 公開日 | 2019-09-11 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
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6KIU
 | | Cryo-EM structure of human MLL1-ubNCP complex (3.2 angstrom) | | 分子名称: | DNA (145-MER), GLUTAMINE, Histone H2A, ... | | 著者 | Huang, J, Xue, H, Yao, T. | | 登録日 | 2019-07-20 | | 公開日 | 2019-09-11 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
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6KIW
 | | Cryo-EM structure of human MLL3-ubNCP complex (4.0 angstrom) | | 分子名称: | DNA (144-MER), DNA (145-MER), Histone H2A, ... | | 著者 | Huang, J, Xue, H, Yao, T. | | 登録日 | 2019-07-20 | | 公開日 | 2019-09-11 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural basis of nucleosome recognition and modification by MLL methyltransferases.
Nature, 573, 2019
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1NH9
 | | Crystal Structure of a DNA Binding Protein Mja10b from the hyperthermophile Methanococcus jannaschii | | 分子名称: | DNA-binding protein Alba | | 著者 | Wang, G, Bartlam, M, Guo, R, Yang, H, Xue, H, Liu, Y, Huang, L, Rao, Z. | | 登録日 | 2002-12-19 | | 公開日 | 2003-12-23 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of a DNA binding protein from the hyperthermophilic euryarchaeon Methanococcus jannaschii
Protein Sci., 12, 2003
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3WFV
 | | HIV-1 CRF07 gp41 | | 分子名称: | Envelope glycoprotein gp160 | | 著者 | Du, J, Xue, H, Ma, J, Liu, F, Zhou, J, Shao, Y, Qiao, W, Liu, X. | | 登録日 | 2013-07-24 | | 公開日 | 2013-10-16 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The crystal structure of HIV CRF07 B'/C gp41 reveals a hyper-mutant site in the middle of HR2 heptad repeat
Virology, 446, 2013
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6LK0
 | | Crystal structure of human wild type TRIP13 | | 分子名称: | Pachytene checkpoint protein 2 homolog | | 著者 | Wang, Y, Huang, J, Li, B, Xue, H, Tricot, G, Hu, L, Xu, Z, Sun, X, Chang, S, Gao, L, Tao, Y, Xu, H, Xie, Y, Xiao, W, Yu, D, Kong, Y, Chen, G, Sun, X, Lian, F, Zhang, N, Wu, X, Mao, Z, Zhan, F, Zhu, W, Shi, J. | | 登録日 | 2019-12-17 | | 公開日 | 2020-01-22 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | A Small-Molecule Inhibitor Targeting TRIP13 Suppresses Multiple Myeloma Progression.
Cancer Res., 80, 2020
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5XGR
 | | Structure of the S1 subunit C-terminal domain from bat-derived coronavirus HKU5 spike protein | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1 | | 著者 | Xue, H, Qi, J, Song, H, Qihui, W, Shi, Y, Gao, G.F. | | 登録日 | 2017-04-16 | | 公開日 | 2017-05-10 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure of the S1 subunit C-terminal domain from bat-derived coronavirus HKU5 spike protein
Virology, 507, 2017
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7V7M
 | | crystal structure of SARS-CoV-2 3CL protease | | 分子名称: | 3C-like proteinase | | 著者 | Yi, Y, Zhang, M, Ye, M. | | 登録日 | 2021-08-21 | | 公開日 | 2022-06-29 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Schaftoside inhibits 3CL pro and PL pro of SARS-CoV-2 virus and regulates immune response and inflammation of host cells for the treatment of COVID-19.
Acta Pharm Sin B, 12, 2022
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7VU5
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7RE8
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7RE9
 | | TCR mimic antibody (Fab fragment) | | 分子名称: | DI(HYDROXYETHYL)ETHER, Fab heavy chain, Fab light chain | | 著者 | Dasgupta, M, Baker, B.M. | | 登録日 | 2021-07-12 | | 公開日 | 2022-07-27 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | | 主引用文献 | Validation and promise of a TCR mimic antibody for cancer immunotherapy of hepatocellular carcinoma.
Sci Rep, 12, 2022
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7RE7
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4XHR
 | | Structure of a phospholipid trafficking complex, native | | 分子名称: | Mitochondrial distribution and morphology protein 35, Protein UPS1, mitochondrial | | 著者 | Yu, F, He, F, Wang, C, Zhang, P. | | 登録日 | 2015-01-06 | | 公開日 | 2015-07-01 | | 最終更新日 | 2015-08-05 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex
Embo Rep., 16, 2015
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4XIZ
 | | Structure of a phospholipid trafficking complex with substrate | | 分子名称: | 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, Mitochondrial distribution and morphology protein 35, Protein UPS1, ... | | 著者 | Yu, F, He, F, Wang, C, Zhang, P. | | 登録日 | 2015-01-08 | | 公開日 | 2015-07-01 | | 最終更新日 | 2015-09-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex
Embo Rep., 16, 2015
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8HOG
 | | Crystal structure of Bcl-2 in complex with sonrotoclax | | 分子名称: | Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | | 著者 | Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. | | 登録日 | 2022-12-10 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.
Blood, 2024
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8HOH
 | | Crystal structure of Bcl-2 G101V in complex with sonrotoclax | | 分子名称: | Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | | 著者 | Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. | | 登録日 | 2022-12-10 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.
Blood, 2024
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8HOI
 | | Crystal structure of Bcl-2 D103Y in complex with sonrotoclax | | 分子名称: | Apoptosis regulator Bcl-2, FORMIC ACID, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | | 著者 | Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. | | 登録日 | 2022-12-10 | | 公開日 | 2024-01-17 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.
Blood, 2024
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8GP7
 | | Structure of Trioxacarcin A covalently bound to RET G4-DNA | | 分子名称: | DNA (5'-D(*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3'), Trioxacarcin A, bound form | | 著者 | Yin, S, Cao, C. | | 登録日 | 2022-08-25 | | 公開日 | 2023-09-06 | | 最終更新日 | 2024-03-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Trioxacarcin A Interactions with G-Quadruplex DNA Reveal Its Potential New Targets as an Anticancer Agent.
J.Med.Chem., 66, 2023
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7C4U
 | | MicroED structure of orthorhombic Vancomycin at 1.2 A resolution | | 分子名称: | CHLORIDE ION, Vancomycin, vancosamine-(1-2)-beta-D-glucopyranose | | 著者 | Fan, Q, Zhou, H, Li, X, Wang, J. | | 登録日 | 2020-05-18 | | 公開日 | 2020-08-12 | | 最終更新日 | 2021-03-17 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.2 Å) | | 主引用文献 | Precise Control Over Kinetics of Molecular Assembly: Production of Particles with Tunable Sizes and Crystalline Forms.
Angew.Chem.Int.Ed.Engl., 59, 2020
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7C4V
 | | MicroED structure of anorthic Vancomycin at 1.05 A resolution | | 分子名称: | CHLORIDE ION, Vancomycin, vancosamine-(1-2)-beta-D-glucopyranose | | 著者 | Fan, Q, Zhou, H, Li, X, Wang, J. | | 登録日 | 2020-05-18 | | 公開日 | 2020-08-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.05 Å) | | 主引用文献 | Precise Control Over Kinetics of Molecular Assembly: Production of Particles with Tunable Sizes and Crystalline Forms.
Angew.Chem.Int.Ed.Engl., 59, 2020
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7DME
 | | Solution structure of human Aha1 | | 分子名称: | Activator of 90 kDa heat shock protein ATPase homolog 1 | | 著者 | Hu, H, Zhou, C, Zhang, N. | | 登録日 | 2020-12-03 | | 公開日 | 2021-04-21 | | 最終更新日 | 2021-09-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Aha1 Exhibits Distinctive Dynamics Behavior and Chaperone-Like Activity.
Molecules, 26, 2021
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7DMD
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7EA8
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