7C4V

MicroED structure of anorthic Vancomycin at 1.05 A resolution

Summary for 7C4V

• Entry DOI: 10.2210/pdb7c4v/pdb
• EMDB information: 30289
• Related PRD ID: PRD_000204
• Descriptor: Vancomycin, vancosamine-(1-2)-beta-D-glucopyranose, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: microed, vancomycin, superbacteria, antibiotic
• Biological source: Amycolatopsis orientalis
• Total number of polymer chains: 2
• Total formula weight: 2982.09

Authors

Fan, Q.,Zhou, H.,Li, X.,Wang, J. (deposition date: 2020-05-18, release date: 2020-08-12, Last modification date: 2023-11-29)

Primary citation

Fan, Q.,Li, L.,Xue, H.,Zhou, H.,Zhao, L.,Liu, J.,Mao, J.,Wu, S.,Zhang, S.,Wu, C.,Li, X.,Zhou, X.,Wang, J.
Precise Control Over Kinetics of Molecular Assembly: Production of Particles with Tunable Sizes and Crystalline Forms.
Angew.Chem.Int.Ed.Engl., 59:15141-15146, 2020

PubMed Abstract: It has been long-pursued but remains a challenge to precisely manipulate the molecular assembly process to obtain desired functional structures. Reported here is the control over the assembly of solute molecules, by a programmed recrystallization of solvent crystal grains, to form micro/nanoparticles with tunable sizes and crystalline forms. A quantitative correlation between the protocol of recrystallization temperature and the assembly kinetics results in precise control over the size of assembled particles, ranging from single-atom catalysts, pure drug nanoparticles, to sub-millimeter organic-semiconductor single crystals. The extensive regulation of the assembly rates leads to the unique and powerful capability of tuning the stacking of molecules, involving the formation of single crystals of notoriously crystallization-resistant molecules and amorphous structures of molecules with a very high propensity to crystallize, which endows it with wide-ranging applications.

PubMed: 32432368
DOI: 10.1002/anie.202003922

Experimental method

ELECTRON CRYSTALLOGRAPHY (1.05 Å)