3WFV

HIV-1 CRF07 gp41

Summary for 3WFV

• Entry DOI: 10.2210/pdb3wfv/pdb
• Descriptor: Envelope glycoprotein gp160 (2 entities in total)
• Functional Keywords: double helix, alpha-helix, virus fusion, glycoprotein, membrane, viral protein
• Biological source: Human immunodeficiency virus 1; More
• Total number of polymer chains: 1
• Total formula weight: 9745.81

Authors

Du, J.,Xue, H.,Ma, J.,Liu, F.,Zhou, J.,Shao, Y.,Qiao, W.,Liu, X. (deposition date: 2013-07-24, release date: 2013-10-16, Last modification date: 2024-03-20)

Primary citation

Du, J.,Xue, H.,Ma, J.,Liu, F.,Zhou, J.,Shao, Y.,Qiao, W.,Liu, X.
The crystal structure of HIV CRF07 B'/C gp41 reveals a hyper-mutant site in the middle of HR2 heptad repeat
Virology, 446:86-94, 2013

PubMed Abstract: HIV CRF07 B'/C is a strain circulating mainly in northwest region of China. The gp41 region of CRF07 is derived from a clade C virus. In order to compare the difference of CRF07 gp41 with that of typical clade B virus, we solved the crystal structure of the core region of CRF07 gp41. Compared with clade B gp41, CRF07 gp41 evolved more basic and hydrophilic residues on its helix bundle surface. Based on sequence alignment, a hyper-mutant cluster located in the middle of HR2 heptads repeat was identified. The mutational study of these residues revealed that this site is important in HIV mediated cell-cell fusion and plays critical roles in conformational changes during viral invasion.

PubMed: 24074570
DOI: 10.1016/j.virol.2013.07.024

Experimental method

X-RAY DIFFRACTION (1.8 Å)