6LK0

Crystal structure of human wild type TRIP13

Summary for 6LK0

• Entry DOI: 10.2210/pdb6lk0/pdb
• Descriptor: Pachytene checkpoint protein 2 homolog (2 entities in total)
• Functional Keywords: aaa+ atpase, hexamer helical filament, atp-bound, conformation dynamic, oncoprotein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 48694.72

Authors

Wang, Y.,Huang, J.,Li, B.,Xue, H.,Tricot, G.,Hu, L.,Xu, Z.,Sun, X.,Chang, S.,Gao, L.,Tao, Y.,Xu, H.,Xie, Y.,Xiao, W.,Yu, D.,Kong, Y.,Chen, G.,Sun, X.,Lian, F.,Zhang, N.,Wu, X.,Mao, Z.,Zhan, F.,Zhu, W.,Shi, J. (deposition date: 2019-12-17, release date: 2020-01-22, Last modification date: 2024-03-27)

• Primary citation: Wang, Y.,Huang, J.,Li, B.,Xue, H.,Tricot, G.,Hu, L.,Xu, Z.,Sun, X.,Chang, S.,Gao, L.,Tao, Y.,Xu, H.,Xie, Y.,Xiao, W.,Yu, D.,Kong, Y.,Chen, G.,Sun, X.,Lian, F.,Zhang, N.,Wu, X.,Mao, Z.,Zhan, F.,Zhu, W.,Shi, J.; A Small-Molecule Inhibitor Targeting TRIP13 Suppresses Multiple Myeloma Progression.; Cancer Res., 80:536-548, 2020; PubMed: 31732653; DOI: 10.1158/0008-5472.CAN-18-3987

Experimental method

X-RAY DIFFRACTION (2.6 Å)