8HOH
Crystal structure of Bcl-2 G101V in complex with sonrotoclax
Summary for 8HOH
Entry DOI | 10.2210/pdb8hoh/pdb |
Descriptor | Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide (3 entities in total) |
Functional Keywords | inhibitor, apoptosis |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 19908.26 |
Authors | |
Primary citation | Liu, J.,Li, S.,Wang, Q.,Feng, Y.,Xing, H.,Yang, X.,Guo, Y.,Guo, Y.,Sun, H.,Liu, X.,Yang, S.,Mei, Z.,Zhu, Y.,Cheng, Z.,Chen, S.,Xu, M.,Zhang, W.,Wan, N.,Wang, J.,Ma, Y.,Zhang, S.,Luan, X.,Xu, A.,Li, L.,Wang, H.,Yang, X.,Hong, Y.,Xue, H.,Yuan, X.,Hu, N.,Song, X.,Wang, Z.,Liu, X.,Wang, L.,Liu, Y. Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy. Blood, 143:1825-1836, 2024 Cited by PubMed: 38211332DOI: 10.1182/blood.2023019706 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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