8GP7

Structure of Trioxacarcin A covalently bound to RET G4-DNA

Summary for 8GP7

• Entry DOI: 10.2210/pdb8gp7/pdb
• Descriptor: DNA (5'-D(*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3'), Trioxacarcin A, bound form (2 entities in total)
• Functional Keywords: g-quadruplex, dna
• Biological source: synthetic construct
• Total number of polymer chains: 1
• Total formula weight: 7272.94

Authors

Yin, S.,Cao, C. (deposition date: 2022-08-25, release date: 2023-09-06, Last modification date: 2024-05-15)

• Primary citation: Yin, S.,Lan, W.,Hou, X.,Liu, Z.,Xue, H.,Wang, C.,Tang, G.L.,Cao, C.; Trioxacarcin A Interactions with G-Quadruplex DNA Reveal Its Potential New Targets as an Anticancer Agent.; J.Med.Chem., 66:6798-6810, 2023; PubMed: 37154782; DOI: 10.1021/acs.jmedchem.3c00178

Experimental method

SOLUTION NMR