7EA8

Human SETD2 bound to a nucleosome containing oncohistone mutations

Summary for 7EA8

• Entry DOI: 10.2210/pdb7ea8/pdb
• EMDB information: 31040
• Descriptor: Histone-lysine N-methyltransferase SETD2, Histone H3.3, Histone H4, ... (9 entities in total)
• Functional Keywords: setd2, methyltransferase, nucleosome, h3.3k36m, gene regulation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 11
• Total formula weight: 195844.55

Authors

Jing, H.,Liu, Y. (deposition date: 2021-03-06, release date: 2021-07-14, Last modification date: 2024-03-27)

• Primary citation: Liu, Y.,Zhang, Y.,Xue, H.,Cao, M.,Bai, G.,Mu, Z.,Yao, Y.,Sun, S.,Fang, D.,Huang, J.; Cryo-EM structure of SETD2/Set2 methyltransferase bound to a nucleosome containing oncohistone mutations.; Cell Discov, 7:32-32, 2021; PubMed: 33972509; DOI: 10.1038/s41421-021-00261-6

Experimental method

ELECTRON MICROSCOPY (3.1 Å)