7EA8
Human SETD2 bound to a nucleosome containing oncohistone mutations
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Histone-lysine N-methyltransferase SETD2 | polymer | 245 | 28580.5 | 1 | UniProt (Q9BYW2) Pfam (PF17907) Pfam (PF00856) | Homo sapiens (Human) | HIF-1,Huntingtin yeast partner B,Huntingtin-interacting protein 1,HIP-1,Huntingtin-interacting protein B,Lysine N-methyltransferase 3A,Protein-lysine N-methyltransferase SETD2,SET domain-containing protein 2,hSET2,p231HBP |
| 2 | B, F (A, E) | Histone H3.3 | polymer | 101 | 11657.6 | 2 | Pfam (PF00125) UniProt (by SIFTS) (Q6PI79) | Homo sapiens (Human) | |
| 3 | C, G (B, F) | Histone H4 | polymer | 78 | 8853.3 | 2 | Pfam (PF15511) UniProt (by SIFTS) (P62799) | Homo sapiens (Human) | |
| 4 | D, H (C, G) | Histone H2A type 1-D | polymer | 104 | 11351.2 | 2 | UniProt (P20671) Pfam (PF00125) Pfam (PF16211) | Homo sapiens (Human) | Histone H2A.3,Histone H2A/g |
| 5 | E, I (D, H) | Histone H2B type 2-E | polymer | 125 | 13820.0 | 2 | UniProt (Q16778) Pfam (PF00125) UniProt (by SIFTS) (P06899) | Homo sapiens (Human) | H2B-clustered histone 21,Histone H2B-GL105,Histone H2B.q,H2B/q |
| 6 | J (I) | 601-DNA | polymer | 122 | 37436.8 | 1 | synthetic construct | ||
| 7 | K (J) | 601-DNA | polymer | 122 | 37868.1 | 1 | synthetic construct | ||
| 8 | L, M, N (L) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 9 | O (L) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 195249.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 594.7 | |
| All* | Total formula weight | 195844.5 |
