7EA8
Human SETD2 bound to a nucleosome containing oncohistone mutations
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | Histone-lysine N-methyltransferase SETD2 | polymer | 245 | 28580.5 | 1 | UniProt (Q9BYW2) Pfam (PF17907) Pfam (PF00856) | Homo sapiens (Human) | HIF-1,Huntingtin yeast partner B,Huntingtin-interacting protein 1,HIP-1,Huntingtin-interacting protein B,Lysine N-methyltransferase 3A,Protein-lysine N-methyltransferase SETD2,SET domain-containing protein 2,hSET2,p231HBP |
| 2 | B, F (A, E) | Histone H3.3 | polymer | 101 | 11657.6 | 2 | Pfam (PF00125) UniProt (by SIFTS) (Q6PI79) | Homo sapiens (Human) | |
| 3 | C, G (B, F) | Histone H4 | polymer | 78 | 8853.3 | 2 | Pfam (PF15511) UniProt (by SIFTS) (P62799) | Homo sapiens (Human) | |
| 4 | D, H (C, G) | Histone H2A type 1-D | polymer | 104 | 11351.2 | 2 | UniProt (P20671) Pfam (PF00125) Pfam (PF16211) | Homo sapiens (Human) | Histone H2A.3,Histone H2A/g |
| 5 | E, I (D, H) | Histone H2B type 2-E | polymer | 125 | 13820.0 | 2 | UniProt (Q16778) Pfam (PF00125) UniProt (by SIFTS) (P06899) | Homo sapiens (Human) | H2B-clustered histone 21,Histone H2B-GL105,Histone H2B.q,H2B/q |
| 6 | J (I) | 601-DNA | polymer | 122 | 37436.8 | 1 | synthetic construct | ||
| 7 | K (J) | 601-DNA | polymer | 122 | 37868.1 | 1 | synthetic construct | ||
| 8 | L, M, N (L) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 9 | O (L) | S-ADENOSYLMETHIONINE | non-polymer | 398.4 | 1 | Chemie (SAM) PubChem (5136) PubChem (34755) PubChem (58633578) PubChem (60038769) PubChem (73897310) PubChem (58766358) PubChem (87224684) PubChem (131697735) PubChem (9865603) PubChem (145712080) PubChem (12312798) PubChem (132988922) PubChem (134692588) PubChem (135030730) PubChem (140459785) PubChem (163046094) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 11 |
| Total formula weight | 195249.9 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 594.7 | |
| All* | Total formula weight | 195844.5 |
