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6WAQ
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BU of 6waq by Molmil
Crystal structure of the SARS-CoV-1 RBD bound by the cross-reactive single-domain antibody SARS VHH-72
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, nanobody SARS VHH-72
Authors:Wrapp, D, McLellan, J.S.
Deposit date:2020-03-25
Release date:2020-04-01
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.
Cell, 181, 2020
6WAR
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BU of 6war by Molmil
Crystal structure of the MERS-CoV RBD bound by the neutralizing single-domain antibody MERS VHH-55
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein, nanobody MERS VHH-55
Authors:Wrapp, D, Torres, G.M, McLellan, J.S.
Deposit date:2020-03-25
Release date:2020-04-08
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies.
Cell, 181, 2020
6U7K
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BU of 6u7k by Molmil
Prefusion structure of PEDV spike
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Wrapp, D, McLellan, J.S.
Deposit date:2019-09-03
Release date:2019-09-18
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.14 Å)
Cite:The 3.1-Angstrom Cryo-electron Microscopy Structure of the Porcine Epidemic Diarrhea Virus Spike Protein in the Prefusion Conformation.
J.Virol., 93, 2019
6VSB
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BU of 6vsb by Molmil
Prefusion 2019-nCoV spike glycoprotein with a single receptor-binding domain up
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Wrapp, D, Wang, N, Corbett, K.S, Goldsmith, J.A, Hsieh, C, Abiona, O, Graham, B.S, McLellan, J.S.
Deposit date:2020-02-10
Release date:2020-02-26
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.46 Å)
Cite:Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Science, 367, 2020
8EU8
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BU of 8eu8 by Molmil
Cryo-EM structure of CH848 10.17DT DS-SOSIP-2P Env
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CH848 10.17DT SOSIP Envelope glycoprotein gp160
Authors:Wrapp, D, Acharya, P, Haynes, B.F.
Deposit date:2022-10-18
Release date:2023-01-04
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.73 Å)
Cite:Structure-Based Stabilization of SOSIP Env Enhances Recombinant Ectodomain Durability and Yield.
J.Virol., 97, 2023
7KBB
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BU of 7kbb by Molmil
Cryo-EM structure of the HCMV pentamer bound by Fabs 2-18 and 8I21
Descriptor: 2-18 Fab Heavy Chain, 2-18 Fab Light Chain, 8I21 Fab Heavy Chain, ...
Authors:Wrapp, D, McLellan, J.S.
Deposit date:2020-10-01
Release date:2021-08-11
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (4.02 Å)
Cite:Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies.
Sci Adv, 8, 2022
7KBA
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BU of 7kba by Molmil
Crystal structure of the HCMV pentamer-specific Fab 2-18
Descriptor: 2-18 Fab Heavy Chain, 2-18 Fab Light Chain
Authors:Wrapp, D, McLellan, J.S.
Deposit date:2020-10-01
Release date:2021-08-11
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies.
Sci Adv, 8, 2022
7M1C
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BU of 7m1c by Molmil
Crystal structure of the HCMV pentamer-specific antibody 1-32
Descriptor: 1-32 Fab Heavy Chain, 1-32 Fab Light Chain
Authors:Wrapp, D, McLellan, J.S.
Deposit date:2021-03-12
Release date:2021-08-11
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies.
Sci Adv, 8, 2022
7LYV
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BU of 7lyv by Molmil
Crystal structure of the HCMV pentamer-specific antibody 1-103
Descriptor: 1-103 Fab Heavy Chain, 1-103 Fab Light Chain
Authors:Wrapp, D, Jones, H.G, McLellan, J.S.
Deposit date:2021-03-08
Release date:2021-08-11
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies.
Sci Adv, 8, 2022
7M30
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BU of 7m30 by Molmil
Cryo-EM structure of the HCMV pentamer bound by antibodies 1-103, 1-32 and 2-25
Descriptor: 1-103 Fab Heavy Chain, 1-103 Fab Light Chain, 1-32 Fab Heavy Chain, ...
Authors:Wrapp, D, McLellan, J.S.
Deposit date:2021-03-17
Release date:2021-08-11
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.81 Å)
Cite:Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies.
Sci Adv, 8, 2022
7M22
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BU of 7m22 by Molmil
Cryo-EM structure of the HCMV pentamer bound by human neuropilin 2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Envelope glycoprotein UL130, ...
Authors:Wrapp, D, McLellan, J.S.
Deposit date:2021-03-15
Release date:2021-08-11
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies.
Sci Adv, 8, 2022
7LYW
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BU of 7lyw by Molmil
Crystal structure of the HCMV pentamer-specific antibody 2-25
Descriptor: 2-25 Fab Heavy Chain, 2-25 Fab Light Chain
Authors:Wrapp, D, Mishra, A.K, McLellan, J.S.
Deposit date:2021-03-08
Release date:2021-08-11
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies.
Sci Adv, 8, 2022
6XKL
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BU of 6xkl by Molmil
SARS-CoV-2 HexaPro S One RBD up
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
Authors:Wrapp, D, Hsieh, C.-L, Goldsmith, J.A, McLellan, J.S.
Deposit date:2020-06-26
Release date:2020-07-15
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structure-based design of prefusion-stabilized SARS-CoV-2 spikes.
Science, 369, 2020
9OFP
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BU of 9ofp by Molmil
HCoV-229E S2P bound by two DH1533 Fabs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1533 heavy chain, ...
Authors:Wrapp, D.
Deposit date:2025-04-30
Release date:2025-12-03
Last modified:2026-02-18
Method:ELECTRON MICROSCOPY (3.16 Å)
Cite:A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain.
Commun Biol, 9, 2025
9OFQ
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BU of 9ofq by Molmil
HCoV-229E S2P bound by one DH1533 Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1533 FAB heavy chain, ...
Authors:Wrapp, D.
Deposit date:2025-04-30
Release date:2025-12-03
Last modified:2026-02-18
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain.
Commun Biol, 9, 2025
9OFO
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BU of 9ofo by Molmil
HCoV-229E S2P bound by three DH1533 Fabs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1533 FAB heavy chain, ...
Authors:Wrapp, D.
Deposit date:2025-04-30
Release date:2025-12-03
Last modified:2026-02-18
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:A neutralizing human antibody induces movement of the HCoV-229E receptor binding domain.
Commun Biol, 9, 2025
6UOE
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BU of 6uoe by Molmil
3-25 Fab germline-reversion variant bound to an HCMV gB-derived peptide
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-25 Fab heavy chain, 3-25 Fab light chain, ...
Authors:Wrapp, D, McLellan, J.S.
Deposit date:2019-10-14
Release date:2020-07-29
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step.
Plos Pathog., 16, 2020
8DF1
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BU of 8df1 by Molmil
Chi3l1 bound by antibody C59
Descriptor: C59 Fab Heavy chain, C59 Fab Light chain, Chitinase-3-like protein 1, ...
Authors:Wrapp, D, McLellan, J.S.
Deposit date:2022-06-21
Release date:2023-03-01
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:A novel humanized Chi3l1 blocking antibody attenuates acetaminophen-induced liver injury in mice.
Antib Ther, 6, 2023
5TP3
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BU of 5tp3 by Molmil
Crystal structure of the RSV-neutralizing single-domain antibody F-VHH-4
Descriptor: F-VHH-4
Authors:Wrapp, D, Gilman, M.S.A, McLellan, J.S.
Deposit date:2016-10-19
Release date:2017-02-22
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.874 Å)
Cite:Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.
Nat Commun, 8, 2017
9NW7
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BU of 9nw7 by Molmil
CA117v2v8 Fab bound to HLA-E-VL9
Descriptor: Beta-2-microglobulin, CA117v2v8 heavy chain, CA117v2v8 light chain, ...
Authors:Wrapp, D, Hwang, J.K, Marston, D.J, Haynes, B.F, Azoitei, M.L.
Deposit date:2025-03-21
Release date:2026-03-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:HLA-E-VL9 antibodies mediate NKG2A+ NK cell and CD8+ T cell killing of HIV-infected CD4+ T cells
To Be Published
9NW9
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BU of 9nw9 by Molmil
CA117v2v8 Fab bound to HLA-E-RL9HIV
Descriptor: Beta-2-microglobulin, CA117v2v8 heavy chain, CA117v2v8 light chain, ...
Authors:Wrapp, D, Hwang, J.K, Marston, D.J, Haynes, B.F, Azoitei, M.L.
Deposit date:2025-03-21
Release date:2026-03-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:HLA-E-VL9 antibodies mediate NKG2A+ NK cell and CD8+ T cell killing of HIV-infected CD4+ T cells
To Be Published
9NW6
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BU of 9nw6 by Molmil
CA147v24 Fab bound to HLA-E-VL9
Descriptor: Beta-2-microglobulin, CA147v24 heavy chain, CA147v24 light chain, ...
Authors:Wrapp, D, Hwang, J.K, Marston, D.J, Haynes, B.F, Azoitei, M.L.
Deposit date:2025-03-21
Release date:2026-03-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:HLA-E-VL9 antibodies mediate NKG2A+ NK cell and CD8+ T cell killing of HIV-infected CD4+ T cells
To Be Published
9NW8
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BU of 9nw8 by Molmil
CA117v2v8 Fab bound to HLA-E-Mtb44
Descriptor: Beta-2-microglobulin, CA117v2v8 heavy chain, CA117v2v8 light chain, ...
Authors:Wrapp, D, Hwang, J.K, Marston, D.J, Haynes, B.F, Azoitei, M.L.
Deposit date:2025-03-21
Release date:2026-03-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:HLA-E-VL9 antibodies mediate NKG2A+ NK cell and CD8+ T cell killing of HIV-infected CD4+ T cells
To Be Published
9NW5
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BU of 9nw5 by Molmil
3H4v31 anti-HLA-E-VL9 Fab
Descriptor: 3H4v31 heavy chain, 3H4v31 light chain
Authors:Wrapp, D, Hwang, J.K, Marston, D.J, Haynes, B.F, Azoitei, M.L.
Deposit date:2025-03-21
Release date:2026-03-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:HLA-E-VL9 antibodies mediate NKG2A+ NK cell and CD8+ T cell killing of HIV-infected CD4+ T cells
To Be Published
6APD
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BU of 6apd by Molmil
Crystal structure of RSV F bound by AM22 and the infant antibody ADI-19425
Descriptor: AM22 Fab Heavy Chain,IGH@ protein, AM22 Fab Light Chain,Uncharacterized protein, Fusion glycoprotein F0,Envelope glycoprotein, ...
Authors:Wrapp, D, McLellan, J.S.
Deposit date:2017-08-17
Release date:2018-03-21
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (4.1 Å)
Cite:Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation.
Immunity, 48, 2018

 

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