7M22

Cryo-EM structure of the HCMV pentamer bound by human neuropilin 2

Summary for 7M22

Entry DOI	10.2210/pdb7m22/pdb
EMDB information	23629
Descriptor	Envelope protein UL128, Envelope glycoprotein UL130, UL131A, ... (6 entities in total)
Functional Keywords	hcmv pentamer, nrp2, cytomegalovirus, host receptor, viral protein, viral protein-host receptor complex, viral protein/host receptor
Biological source	Human cytomegalovirus (HHV-5) More
Total number of polymer chains	4
Total formula weight	117364.36
Authors	Wrapp, D.,McLellan, J.S. (deposition date: 2021-03-15, release date: 2021-08-11, Last modification date: 2022-03-23)
Primary citation	Wrapp, D.,Ye, X.,Ku, Z.,Su, H.,Jones, H.G.,Wang, N.,Mishra, A.K.,Freed, D.C.,Li, F.,Tang, A.,Li, L.,Jaijyan, D.K.,Zhu, H.,Wang, D.,Fu, T.M.,Zhang, N.,An, Z.,McLellan, J.S. Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies. Sci Adv, 8:eabm2546-eabm2546, 2022 Cited by PubMed: 35275718 DOI: 10.1126/sciadv.abm2546 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.65 Å)

Structure validation