7M22
Cryo-EM structure of the HCMV pentamer bound by human neuropilin 2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (C) | Envelope protein UL128 | polymer | 144 | 16684.3 | 1 | UniProt (C8BLJ3) UniProt (by SIFTS) (P16837) | Human cytomegalovirus (HHV-5) | UL128 |
| 2 | B (D) | Envelope glycoprotein UL130 | polymer | 189 | 21761.7 | 1 | UniProt (A0A0G2TB82) Pfam (PF11668) UniProt (by SIFTS) (P16772) | Human cytomegalovirus (HHV-5) | ORFL272C_UL130,UL130 protein |
| 3 | C (E) | UL131A | polymer | 111 | 13005.5 | 1 | UniProt (Q38M21) UniProt (by SIFTS) (F5HET4) | Human cytomegalovirus (HHV-5) | |
| 4 | D (N) | Neuropilin-2 | polymer | 581 | 65430.4 | 1 | UniProt (O60462) Pfam (PF00431) Pfam (PF00754) | Homo sapiens (Human) | Vascular endothelial cell growth factor 165 receptor 2 |
| 5 | E, G (E, N) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | F (N) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) |
Sequence modifications
N: 23 - 595 (UniProt: O60462)
| PDB | External Database | Details |
|---|---|---|
| Gly 596 | - | expression tag |
| Ser 597 | - | expression tag |
| Leu 598 | - | expression tag |
| Glu 599 | - | expression tag |
| Val 600 | - | expression tag |
| Leu 601 | - | expression tag |
| Phe 602 | - | expression tag |
| Gln 603 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 116881.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 482.5 | |
| All* | Total formula weight | 117364.4 |
