7M30

Cryo-EM structure of the HCMV pentamer bound by antibodies 1-103, 1-32 and 2-25

Summary for 7M30

• Entry DOI: 10.2210/pdb7m30/pdb
• EMDB information: 23640
• Descriptor: Envelope glycoprotein L, 1-103 Fab Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (11 entities in total)
• Functional Keywords: hcmv pentamer, fab, cytomegalovirus, immunocomplex, viral protein, viral protein-immune system complex, viral protein/immune system
• Biological source: Human cytomegalovirus (HHV-5, Human herpesvirus 5); More
• Total number of polymer chains: 10
• Total formula weight: 224409.68

Authors

Wrapp, D.,McLellan, J.S. (deposition date: 2021-03-17, release date: 2021-08-11, Last modification date: 2022-03-23)

• Primary citation: Wrapp, D.,Ye, X.,Ku, Z.,Su, H.,Jones, H.G.,Wang, N.,Mishra, A.K.,Freed, D.C.,Li, F.,Tang, A.,Li, L.,Jaijyan, D.K.,Zhu, H.,Wang, D.,Fu, T.M.,Zhang, N.,An, Z.,McLellan, J.S.; Structural basis for HCMV Pentamer recognition by neuropilin 2 and neutralizing antibodies.; Sci Adv, 8:eabm2546-eabm2546, 2022; PubMed: 35275718; DOI: 10.1126/sciadv.abm2546

Experimental method

ELECTRON MICROSCOPY (3.81 Å)