6LPI
 
 | | Crystal Structure of AHAS holo-enzyme | | 分子名称: | Acetolactate synthase isozyme 1 large subunit, Acetolactate synthase isozyme 1 small subunit, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Zhang, Y, Yang, X, Xi, Z, Shen, Y. | | 登録日 | 2020-01-10 | | 公開日 | 2020-11-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.849 Å) | | 主引用文献 | Molecular architecture of the acetohydroxyacid synthase holoenzyme.
Biochem.J., 477, 2020
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7FAS
 | | VAR2CSA 3D7 ectodomain core region | | 分子名称: | Erythrocyte membrane protein 1, PfEMP1 | | 著者 | Wang, L, Zhaoning, W. | | 登録日 | 2021-07-07 | | 公開日 | 2021-11-17 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum.
Cell Discov, 7, 2021
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7FAP
 | | Structure of VAR2CSA-CSA 3D7 | | 分子名称: | 2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-3)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid, Erythrocyte membrane protein 1, PfEMP1 | | 著者 | Wang, L, Wang, Z. | | 登録日 | 2021-07-07 | | 公開日 | 2022-05-04 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum.
Cell Discov, 7, 2021
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5UJ8
 | | Human Origin Recognition Complex subunits 2 and 3 | | 分子名称: | Origin recognition complex subunit 2, Origin recognition complex subunit 3 | | 著者 | Tocilj, A, On, K.F, Elkayam, E, Joshua-Tor, L. | | 登録日 | 2017-01-17 | | 公開日 | 2017-02-08 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (6 Å) | | 主引用文献 | Structure of the active form of human Origin Recognition Complex and its ATPase motor module.
Elife, 6, 2017
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5UJ7
 | | Structure of the active form of human Origin Recognition Complex ATPase motor module, complex subunitS 1, 4, 5 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... | | 著者 | Tocilj, A, Elkayam, E, On, K.F, Joshua-Tor, L. | | 登録日 | 2017-01-17 | | 公開日 | 2017-02-08 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.394 Å) | | 主引用文献 | Structure of the active form of human Origin Recognition Complex and its ATPase motor module.
Elife, 6, 2017
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5W6V
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7WWF
 | | Crystal structure of BioH3 from Mycolicibacterium smegmatis | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, Esterase | | 著者 | Yang, J, Xu, Y.C, Gan, J.H, Feng, Y.J. | | 登録日 | 2022-02-12 | | 公開日 | 2022-07-06 | | 最終更新日 | 2023-01-18 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Three enigmatic BioH isoenzymes are programmed in the early stage of mycobacterial biotin synthesis, an attractive anti-TB drug target.
Plos Pathog., 18, 2022
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4OJN
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1L2J
 | | Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol | | 分子名称: | (R,R)-5,11-CIS-DIETHYL-5,6,11,12-TETRAHYDROCHRYSENE-2,8-DIOL, ESTROGEN RECEPTOR BETA | | 著者 | Shiau, A.K, Barstad, D, Radek, J.T, Meyers, M.J, Nettles, K.W, Katzenellenbogen, B.S, Katzenellenbogen, J.A, Agard, D.A, Greene, G.L. | | 登録日 | 2002-02-21 | | 公開日 | 2002-05-01 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.
Nat.Struct.Biol., 9, 2002
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4OKN
 | | Crystal structure of human muscle L-lactate dehydrogenase, ternary complex with NADH and oxalate | | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, KANAMYCIN A, L-lactate dehydrogenase A chain, ... | | 著者 | Kolappan, S, Craig, L. | | 登録日 | 2014-01-22 | | 公開日 | 2014-12-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms.
Acta Crystallogr.,Sect.D, 71, 2015
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4QT0
 | | Crystal structure of human muscle L-lactate dehydrogenase in complex with inhibitor 1, 3-{[3-CARBAMOYL-7-(2,4-DIMETHOXYPYRIMIDIN-5-YL)QUINOLIN-4-YL]AMINO}BENZOIC ACID | | 分子名称: | 3-{[3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino}benzoic acid, L-lactate dehydrogenase A chain | | 著者 | Kolappan, S, Craig, L. | | 登録日 | 2014-07-06 | | 公開日 | 2014-12-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms.
Acta Crystallogr.,Sect.D, 71, 2015
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4QSM
 | | Crystal structure of human muscle L-lactate dehydrogenase in complex with inhibitor 2, 3-{[7-(2,4-dimethoxypyrimidin-5-yl)-3-sulfamoylquinolin-4-yl]amino}benzoic acid | | 分子名称: | 3-{[7-(2,4-dimethoxypyrimidin-5-yl)-3-sulfamoylquinolin-4-yl]amino}benzoic acid, L-lactate dehydrogenase A chain | | 著者 | Kolappan, S, Craig, L. | | 登録日 | 2014-07-06 | | 公開日 | 2014-12-03 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms.
Acta Crystallogr.,Sect.D, 71, 2015
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3LEA
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8JLZ
 | | ST1936-5HT6R complex | | 分子名称: | 2-(5-chloranyl-2-methyl-1~{H}-indol-3-yl)-N,N-dimethyl-ethanamine, 5-hydroxytryptamine receptor 6, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Wen, X, Sun, J. | | 登録日 | 2023-06-04 | | 公開日 | 2023-06-28 | | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | | 主引用文献 | Structural insight into the selective agonist ST1936 binding of serotonin receptor 5-HT6.
Biochem.Biophys.Res.Commun., 671, 2023
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3LE9
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7D4B
 | | Crystal structure of 4-1BB in complex with a VHH | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | | 著者 | Wang, C. | | 登録日 | 2020-09-23 | | 公開日 | 2021-07-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.14 Å) | | 主引用文献 | Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer.
J Immunother Cancer, 9, 2021
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7CZD
 | | Crystal structure of PD-L1 in complex with a VHH | | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Programmed cell death 1 ligand 1, ... | | 著者 | Wang, C. | | 登録日 | 2020-09-08 | | 公開日 | 2021-07-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer.
J Immunother Cancer, 9, 2021
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7FH5
 | | Structure of AdaV | | 分子名称: | AdaV, CHLORIDE ION, FE (III) ION | | 著者 | Zhang, Z.Y, Chen, W.Q, Zhai, G.Q, Zhang, M. | | 登録日 | 2021-07-29 | | 公開日 | 2022-08-03 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural Insight into the Catalytic Mechanism of Non-Heme Iron Halogenase AdaV in 2'-Chloropentostatin Biosynthesis
Acs Catalysis, 12, 2022
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5Z30
 | | The crystal structure of the nucleosome containing a cancer-associated histone H2A.Z R80C mutant | | 分子名称: | CHLORIDE ION, DNA (146-MER), Histone H2A.Z, ... | | 著者 | Horikoshi, N, Arimura, Y, Kurumizaka, H. | | 登録日 | 2018-01-05 | | 公開日 | 2018-07-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome.
Nucleic Acids Res., 46, 2018
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7V56
 | | Structure of AdaV | | 分子名称: | AdaV, FE (III) ION | | 著者 | Zhang, Z.Y, Chen, W.Q, Zhai, G.Q, Zhang, M. | | 登録日 | 2021-08-16 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-03-01 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Structural Insight into the Catalytic Mechanism of Non-Heme Iron Halogenase AdaV in 2'-Chloropentostatin Biosynthesis
Acs Catalysis, 12, 2022
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7V52
 | | Structure of AdaV | | 分子名称: | AdaV, FE (III) ION | | 著者 | Zhang, Z.Y, Chen, W.Q, Zhai, G.Q, Zhang, M. | | 登録日 | 2021-08-16 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-03-01 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | Structural Insight into the Catalytic Mechanism of Non-Heme Iron Halogenase AdaV in 2'-Chloropentostatin Biosynthesis
Acs Catalysis, 12, 2022
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7V57
 | | Structure of AdaV | | 分子名称: | 2-OXOGLUTARIC ACID, AdaV, CHLORIDE ION, ... | | 著者 | Zhang, Z.Y, Chen, W.Q, Zhai, G.Q, Zhang, M. | | 登録日 | 2021-08-16 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-03-01 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural Insight into the Catalytic Mechanism of Non-Heme Iron Halogenase AdaV in 2'-Chloropentostatin Biosynthesis
Acs Catalysis, 12, 2022
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7V54
 | | Structure of AdaV | | 分子名称: | AdaV, FE (III) ION | | 著者 | Zhang, Z.Y, Chen, W.Q, Zhai, G.Q, Zhang, M. | | 登録日 | 2021-08-16 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-03-01 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Structural Insight into the Catalytic Mechanism of Non-Heme Iron Halogenase AdaV in 2'-Chloropentostatin Biosynthesis
Acs Catalysis, 12, 2022
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7V7X
 | | Structure of H194A AdaV | | 分子名称: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, AdaV | | 著者 | Zhang, Z.Y, Chen, W.Q, Zhai, G.Q, Zhang, M. | | 登録日 | 2021-08-22 | | 公開日 | 2022-08-31 | | 最終更新日 | 2023-03-01 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural Insight into the Catalytic Mechanism of Non-Heme Iron Halogenase AdaV in 2'-Chloropentostatin Biosynthesis
Acs Catalysis, 12, 2022
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7VM8
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