4QSM

Crystal structure of human muscle L-lactate dehydrogenase in complex with inhibitor 2, 3-{[7-(2,4-dimethoxypyrimidin-5-yl)-3-sulfamoylquinolin-4-yl]amino}benzoic acid

Summary for 4QSM

Entry DOI	10.2210/pdb4qsm/pdb
Related	4OJN 4OKN 4QT0
Descriptor	L-lactate dehydrogenase A chain, 3-{[7-(2,4-dimethoxypyrimidin-5-yl)-3-sulfamoylquinolin-4-yl]amino}benzoic acid (3 entities in total)
Functional Keywords	rossmann fold, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00338
Total number of polymer chains	8
Total formula weight	303310.60
Authors	Kolappan, S.,Craig, L. (deposition date: 2014-07-06, release date: 2014-12-03, Last modification date: 2024-02-28)
Primary citation	Kolappan, S.,Shen, D.L.,Mosi, R.,Sun, J.,McEachern, E.J.,Vocadlo, D.J.,Craig, L. Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallogr.,Sect.D, 71:185-195, 2015 Cited by PubMed: 25664730 DOI: 10.1107/S1399004714024791 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation