4QSM

Crystal structure of human muscle L-lactate dehydrogenase in complex with inhibitor 2, 3-{[7-(2,4-dimethoxypyrimidin-5-yl)-3-sulfamoylquinolin-4-yl]amino}benzoic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	L-lactate dehydrogenase A chain	polymer	337	37432.3	8	UniProt (P00338) Pfam (PF00056) Pfam (PF02866) In PDB	Homo sapiens (human)	LDH-A, Cell proliferation-inducing gene 19 protein, LDH muscle subunit, LDH-M, Renal carcinoma antigen NY-REN-59
2	A, B, C, D, E...	3-{[7-(2,4-dimethoxypyrimidin-5-yl)-3-sulfamoylquinolin-4-yl]amino}benzoic acid	non-polymer		481.5	8	Chemie (38K)
3		water	water		18.0	60	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 2 - 332 (UniProt: P00338)

PDB	External Database	Details
His 333	-	expression tag
His 334	-	expression tag
His 335	-	expression tag
His 336	-	expression tag
His 337	-	expression tag
His 338	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	299458.8
Non-Polymers*	Number of molecules	8
	Total formula weight	3851.8
All*	Total formula weight	303310.6

*Water molecules are not included.