1L2J

Human Estrogen Receptor beta Ligand-binding Domain in Complex with (R,R)-5,11-cis-diethyl-5,6,11,12-tetrahydrochrysene-2,8-diol

Summary for 1L2J

• Entry DOI: 10.2210/pdb1l2j/pdb
• Related: 1L2I 1QKM
• Descriptor: ESTROGEN RECEPTOR BETA, (R,R)-5,11-CIS-DIETHYL-5,6,11,12-TETRAHYDROCHRYSENE-2,8-DIOL (3 entities in total)
• Functional Keywords: nuclear receptor, transcription factor, estrogen, antagonist, transcription receptor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus: Q92731
• Total number of polymer chains: 2
• Total formula weight: 61783.09

Authors

Shiau, A.K.,Barstad, D.,Radek, J.T.,Meyers, M.J.,Nettles, K.W.,Katzenellenbogen, B.S.,Katzenellenbogen, J.A.,Agard, D.A.,Greene, G.L. (deposition date: 2002-02-21, release date: 2002-05-01, Last modification date: 2023-08-16)

• Primary citation: Shiau, A.K.,Barstad, D.,Radek, J.T.,Meyers, M.J.,Nettles, K.W.,Katzenellenbogen, B.S.,Katzenellenbogen, J.A.,Agard, D.A.,Greene, G.L.; Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism.; Nat.Struct.Biol., 9:359-364, 2002; PubMed: 11953755

Experimental method

X-RAY DIFFRACTION (2.95 Å)