3LE9

Crystal structure of the catalytic domain of TACE with Indazolinone-phenyl-hydantoin inhibitor

Summary for 3LE9

• Entry DOI: 10.2210/pdb3le9/pdb
• Related: 1BKC 3L0T 3L0V 3LEA
• Descriptor: Disintegrin and metalloproteinase domain-containing protein 17, ZINC ION, (5R)-5-[(5-methoxy-3-oxo-1,3-dihydro-2H-indazol-2-yl)methyl]-5-phenylimidazolidine-2,4-dione, ... (5 entities in total)
• Functional Keywords: glycoprotein, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, protease, transmembrane, zymogen, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P78536
• Total number of polymer chains: 2
• Total formula weight: 62033.87

Authors

Orth, P. (deposition date: 2010-01-14, release date: 2010-12-08, Last modification date: 2023-09-06)

• Primary citation: Yu, W.,Tong, L.,Kim, S.H.,Wong, M.K.,Chen, L.,Yang, D.Y.,Shankar, B.B.,Lavey, B.J.,Zhou, G.,Kosinski, A.,Rizvi, R.,Li, D.,Feltz, R.J.,Piwinski, J.J.,Rosner, K.E.,Shih, N.Y.,Siddiqui, M.A.,Guo, Z.,Orth, P.,Shah, H.,Sun, J.,Umland, S.,Lundell, D.J.,Niu, X.,Kozlowski, J.A.; Biaryl substituted hydantoin compounds as TACE inhibitors.; Bioorg.Med.Chem.Lett., 20:5286-5289, 2010; PubMed: 20663669; DOI: 10.1016/j.bmcl.2010.06.134

Experimental method

X-RAY DIFFRACTION (1.85 Å)