3L0T

Crystal structure of catalytic domain of TACE with hydantoin inhibitor

Summary for 3L0T

• Entry DOI: 10.2210/pdb3l0t/pdb
• Related: 1BKC 3KMC 3KME 3L0V 3LE9 3LEA
• Related PRD ID: PRD_000919
• Descriptor: Disintegrin and metalloproteinase domain-containing protein 17, ZINC ION, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... (6 entities in total)
• Functional Keywords: metal-binding, metalloprotease, notch signaling pathway, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P78536
• Total number of polymer chains: 2
• Total formula weight: 62038.03

Authors

Orth, P. (deposition date: 2009-12-10, release date: 2010-03-02, Last modification date: 2023-09-06)

• Primary citation: Yu, W.,Guo, Z.,Orth, P.,Madison, V.,Chen, L.,Dai, C.,Feltz, R.J.,Girijavallabhan, V.M.,Kim, S.H.,Kozlowski, J.A.,Lavey, B.J.,Li, D.,Lundell, D.,Niu, X.,Piwinski, J.J.,Popovici-Muller, J.,Rizvi, R.,Rosner, K.E.,Shankar, B.B.,Shih, N.Y.,Siddiqui, M.A.,Sun, J.,Tong, L.,Umland, S.,Wong, M.K.,Yang, D.Y.,Zhou, G.; Discovery and SAR of hydantoin TACE inhibitors.; Bioorg.Med.Chem.Lett., 20:1877-1880, 2010; PubMed: 20172725; DOI: 10.1016/j.bmcl.2010.01.148

Experimental method

X-RAY DIFFRACTION (1.92 Å)