3LEA
Crystal structure of the catalytic domain of TACE with Isoindolinone-biphenyl-hydantoin inhibitor
Summary for 3LEA
Entry DOI | 10.2210/pdb3lea/pdb |
Related | 1bkc 3L0T 3L0V 3LE9 |
Descriptor | Disintegrin and metalloproteinase domain-containing protein 17, 2-{[(4R)-2,5-dioxo-4-(4-pyridin-3-ylphenyl)imidazolidin-4-yl]methyl}-6-methoxy-1-oxo-1H-isoindolium, ZINC ION, ... (5 entities in total) |
Functional Keywords | glycoprotein, membrane, metal-binding, metalloprotease, notch signaling pathway, phosphoprotein, protease, transmembrane, zymogen, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P78536 |
Total number of polymer chains | 2 |
Total formula weight | 62184.05 |
Authors | Orth, P. (deposition date: 2010-01-14, release date: 2010-12-08, Last modification date: 2023-09-06) |
Primary citation | Yu, W.,Tong, L.,Kim, S.H.,Wong, M.K.,Chen, L.,Yang, D.Y.,Shankar, B.B.,Lavey, B.J.,Zhou, G.,Kosinski, A.,Rizvi, R.,Li, D.,Feltz, R.J.,Piwinski, J.J.,Rosner, K.E.,Shih, N.Y.,Siddiqui, M.A.,Guo, Z.,Orth, P.,Shah, H.,Sun, J.,Umland, S.,Lundell, D.J.,Niu, X.,Kozlowski, J.A. Biaryl substituted hydantoin compounds as TACE inhibitors. Bioorg.Med.Chem.Lett., 20:5286-5289, 2010 Cited by PubMed: 20663669DOI: 10.1016/j.bmcl.2010.06.134 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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