4QT0
Crystal structure of human muscle L-lactate dehydrogenase in complex with inhibitor 1, 3-{[3-CARBAMOYL-7-(2,4-DIMETHOXYPYRIMIDIN-5-YL)QUINOLIN-4-YL]AMINO}BENZOIC ACID
Summary for 4QT0
Entry DOI | 10.2210/pdb4qt0/pdb |
Related | 4OJN 4OKN 4QSM |
Descriptor | L-lactate dehydrogenase A chain, 3-{[3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl]amino}benzoic acid (3 entities in total) |
Functional Keywords | rossmann fold, tetramer, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P00338 |
Total number of polymer chains | 8 |
Total formula weight | 303022.17 |
Authors | Kolappan, S.,Craig, L. (deposition date: 2014-07-06, release date: 2014-12-03, Last modification date: 2024-02-28) |
Primary citation | Kolappan, S.,Shen, D.L.,Mosi, R.,Sun, J.,McEachern, E.J.,Vocadlo, D.J.,Craig, L. Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallogr.,Sect.D, 71:185-195, 2015 Cited by PubMed: 25664730DOI: 10.1107/S1399004714024791 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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