5JVD
| Tubulin-TUB092 complex | 分子名称: | (2E)-3-(3-hydroxy-4-methoxyphenyl)-1-(7-methoxy-2H-1,3-benzodioxol-5-yl)-2-methylprop-2-en-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Canela, M.-D, Noppen, S, Bueno, O, Prota, A.E, Bargsten, K, Saez-Calvo, G, Jimeno, M.-L, Benkheil, M, Ribatti, D, Velazquez, S, Camarasa, M.-J, Diaz, J.F, Steinmetz, M.O, Priego, E.-M, Perez-Perez, M.-J, Liekens, S. | 登録日 | 2016-05-11 | 公開日 | 2016-06-08 | 最終更新日 | 2017-09-06 | 実験手法 | X-RAY DIFFRACTION (2.393 Å) | 主引用文献 | Antivascular and antitumor properties of the tubulin-binding chalcone TUB091. Oncotarget, 8, 2017
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8RIV
| T2R-TTL-1-K08 complex | 分子名称: | (4-fluoranyl-2-methyl-1~{H}-indol-5-yl) 3,4,5-trimethoxybenzenesulfonate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Boiarska, Z, Homer, J.A, Steinmetz, M.O, Moses, J.E, Prota, A.E.P. | 登録日 | 2023-12-19 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Modular synthesis of functional libraries by accelerated SuFEx click chemistry. Chem Sci, 15, 2024
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8RIW
| T2R-TTL-1-L01 complex | 分子名称: | (2-methyl-1~{H}-indol-5-yl) 3,4,5-trimethoxybenzenesulfonate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Prota, A.E.P, Boiarska, Z, Homer, J.A, Steinmetz, M.O, Moses, J.E. | 登録日 | 2023-12-19 | 公開日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | Modular synthesis of functional libraries by accelerated SuFEx click chemistry. Chem Sci, 15, 2024
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2AKF
| Crystal structure of the coiled-coil domain of coronin 1 | 分子名称: | Coronin-1A, ZINC ION | 著者 | Kammerer, R.A, Kostrewa, D, Progias, P, Honnappa, S, Avila, D, Lustig, A, Winkler, F.K, Pieters, J, Steinmetz, M.O. | 登録日 | 2005-08-03 | 公開日 | 2005-09-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | A conserved trimerization motif controls the topology of short coiled coils Proc.Natl.Acad.Sci.Usa, 102, 2005
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1WU9
| Crystal structure of the C-terminal domain of the end-binding protein 1 (EB1) | 分子名称: | Microtubule-associated protein RP/EB family member 1 | 著者 | Honnappa, S, John, C.M, Kostrewa, D, Winkler, F.K, Steinmetz, M.O. | 登録日 | 2004-12-02 | 公開日 | 2005-02-01 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Structural insights into the EB1-APC interaction Embo J., 24, 2005
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1Z2B
| Tubulin-colchicine-vinblastine: stathmin-like domain complex | 分子名称: | (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE, 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Gigant, B, Wang, C, Ravelli, R.B.G, Roussi, F, Steinmetz, M.O, Curmi, P.A, Sobel, A, Knossow, M. | 登録日 | 2005-03-08 | 公開日 | 2005-05-31 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (4.1 Å) | 主引用文献 | Structural basis for the regulation of tubulin by vinblastine. Nature, 435, 2005
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3GJP
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3GJO
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3CO1
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3E2U
| Crystal structure of the zink-knuckle 2 domain of human CLIP-170 in complex with CAP-Gly domain of human dynactin-1 (p150-GLUED) | 分子名称: | CAP-Gly domain-containing linker protein 1, Dynactin subunit 1, ZINC ION | 著者 | Weisbrich, A, Honnappa, S, Capitani, G, Steinmetz, M.O. | 登録日 | 2008-08-06 | 公開日 | 2008-08-19 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structure-function relationship of CAP-Gly domains Nat.Struct.Mol.Biol., 14, 2007
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5D3A
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7PJF
| Inhibiting parasite proliferation using a rationally designed anti-tubulin agent | 分子名称: | Designed ankyrin repeat protein (DARPIN) D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Sharma, A, Gaillard, N, Ehrhard, V.A, Steinmetz, M.O. | 登録日 | 2021-08-24 | 公開日 | 2021-09-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.862 Å) | 主引用文献 | Inhibiting parasite proliferation using a rationally designed anti-tubulin agent. Embo Mol Med, 13, 2021
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7PJE
| Inhibiting parasite proliferation using a rationally designed anti-tubulin agent | 分子名称: | Darpin D1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Sharma, A, Gaillard, N, Ehrhard, V.A, Steinmetz, M.O. | 登録日 | 2021-08-24 | 公開日 | 2021-09-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Inhibiting parasite proliferation using a rationally designed anti-tubulin agent. Embo Mol Med, 13, 2021
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1D7M
| COILED-COIL DIMERIZATION DOMAIN FROM CORTEXILLIN I | 分子名称: | CORTEXILLIN I | 著者 | Burkhard, P, Kammerer, R.A, Steinmetz, M.O, Bourenkov, G.P, Aebi, U. | 登録日 | 1999-10-19 | 公開日 | 2000-03-27 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The coiled-coil trigger site of the rod domain of cortexillin I unveils a distinct network of interhelical and intrahelical salt bridges. Structure Fold.Des., 8, 2000
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2L56
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4O4I
| Tubulin-Laulimalide-Epothilone A complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, EPOTHILONE A, ... | 著者 | Prota, A.E, Bargsten, K, Northcote, P.T, Marsh, M, Altmann, K.H, Miller, J.H, Diaz, J.F, Steinmetz, M.O. | 登録日 | 2013-12-18 | 公開日 | 2014-03-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural basis of microtubule stabilization by laulimalide and peloruside a. Angew.Chem.Int.Ed.Engl., 53, 2014
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4O2A
| Tubulin-BAL27862 complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 3-[(4-{1-[2-(4-aminophenyl)-2-oxoethyl]-1H-benzimidazol-2-yl}-1,2,5-oxadiazol-3-yl)amino]propanenitrile, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Prota, A.E, Franck, D, Bachmann, F, Bargsten, K, Buey, R.M, Pohlmann, J, Reinelt, S, Lane, H, Steinmetz, M.O. | 登録日 | 2013-12-17 | 公開日 | 2014-03-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization. J.Mol.Biol., 426, 2014
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4O2B
| Tubulin-Colchicine complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Prota, A.E, Franck, D, Bachmann, F, Bargsten, K, Buey, R.M, Pohlmann, J, Reinelt, S, Lane, H, Steinmetz, M.O. | 登録日 | 2013-12-17 | 公開日 | 2014-03-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization. J.Mol.Biol., 426, 2014
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4O4H
| Tubulin-Laulimalide complex | 分子名称: | CALCIUM ION, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Prota, A.E, Bargsten, K, Northcote, P.T, Marsh, M, Altmann, K.H, Miller, J.H, Diaz, J.F, Steinmetz, M.O. | 登録日 | 2013-12-18 | 公開日 | 2014-03-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis of microtubule stabilization by laulimalide and peloruside a. Angew.Chem.Int.Ed.Engl., 53, 2014
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4O4J
| Tubulin-Peloruside A complex | 分子名称: | CALCIUM ION, GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Prota, A.E, Bargsten, K, Northcote, P.T, Marsh, M, Altmann, K.H, Miller, J.H, Diaz, J.F, Steinmetz, M.O. | 登録日 | 2013-12-18 | 公開日 | 2014-03-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis of microtubule stabilization by laulimalide and peloruside A. Angew.Chem.Int.Ed.Engl., 53, 2014
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4O4L
| Tubulin-Peloruside A-Epothilone A complex | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, EPOTHILONE A, ... | 著者 | Prota, A.E, Bargsten, K, Northcote, P.T, Marsh, M, Altmann, K.H, Miller, J.H, Diaz, J.F, Steinmetz, M.O. | 登録日 | 2013-12-18 | 公開日 | 2014-03-26 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis of microtubule stabilization by laulimalide and peloruside a. Angew.Chem.Int.Ed.Engl., 53, 2014
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3TQ7
| EB1c/EB3c heterodimer in complex with the CAP-Gly domain of P150glued | 分子名称: | Dynactin subunit 1, Microtubule-associated protein RP/EB family member 1, Microtubule-associated protein RP/EB family member 3 | 著者 | De Groot, C.O, Scharer, M.A, Capitani, G, Steinmetz, M.O. | 登録日 | 2011-09-09 | 公開日 | 2012-01-25 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Interaction of mammalian end binding proteins with CAP-Gly domains of CLIP-170 and p150(glued). J.Struct.Biol., 177, 2012
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6Y6D
| Tubulin-7-Aminonoscapine complex | 分子名称: | (3~{S})-7-azanyl-6-methoxy-3-[(5~{R})-4-methoxy-6-methyl-7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3~{H}-2-benzofuran-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Oliva, M.A, Prota, A.E, Rodriguez-Salarichs, J, Gu, W, Bennani, Y.L, Jimenez-Barbero, J, Canales, A, Steinmetz, M.O, Diaz, J.F. | 登録日 | 2020-02-26 | 公開日 | 2020-07-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Basis of Noscapine Activation for Tubulin Binding. J.Med.Chem., 63, 2020
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5FCM
| CrBld10-N 1-70 | 分子名称: | Basal body protein, ISOPROPYL ALCOHOL, SULFATE ION | 著者 | Kraatz, S.H.W, Steinmetz, M.O. | 登録日 | 2015-12-15 | 公開日 | 2016-07-20 | 最終更新日 | 2017-10-18 | 実験手法 | X-RAY DIFFRACTION (2.229 Å) | 主引用文献 | The Human Centriolar Protein CEP135 Contains a Two-Stranded Coiled-Coil Domain Critical for Microtubule Binding. Structure, 24, 2016
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4TV9
| Tubulin-PM060184 complex | 分子名称: | (1Z,4S,6Z)-1-[(N-{(2Z,4Z,6E,8S)-8-[(2S)-5-methoxy-6-oxo-3,6-dihydro-2H-pyran-2-yl]-6-methylnona-2,4,6-trienoyl}-3-methy l-L-valyl)amino]octa-1,6-dien-4-yl carbamate, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Prota, A.E, Bargsten, K, Diaz, J.F, Marsh, M, Cuevas, C, Liniger, M, Neuhaus, C, Andreu, J.M, Altmann, K.H, Steinmetz, M.O. | 登録日 | 2014-06-26 | 公開日 | 2014-08-20 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proc.Natl.Acad.Sci.USA, 111, 2014
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