4TV9

Tubulin-PM060184 complex

Summary for 4TV9

Entry DOI	10.2210/pdb4tv9/pdb
Related	4I4T 4I50 4I55 4IHJ 4IIJ 4O2A 4O2B 4O4H 4O4I 4O4J 4O4L 4TV8
Descriptor	Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (1Z,4S,6Z)-1-[(N-{(2Z,4Z,6E,8S)-8-[(2S)-5-methoxy-6-oxo-3,6-dihydro-2H-pyran-2-yl]-6-methylnona-2,4,6-trienoyl}-3-methy l-L-valyl)amino]octa-1,6-dien-4-yl carbamate, ... (13 entities in total)
Functional Keywords	cell cycle, tubulin fold, cytoskeleton, microtubule
Biological source	Rattus norvegicus (Rat) More
Cellular location	Cytoplasm, cytoskeleton: P81947 Cytoplasm, cytoskeleton (By similarity): Q6B856 Golgi apparatus: P63043
Total number of polymer chains	6
Total formula weight	265222.10
Authors	Prota, A.E.,Bargsten, K.,Diaz, J.F.,Marsh, M.,Cuevas, C.,Liniger, M.,Neuhaus, C.,Andreu, J.M.,Altmann, K.H.,Steinmetz, M.O. (deposition date: 2014-06-26, release date: 2014-08-20, Last modification date: 2023-12-20)
Primary citation	Prota, A.E.,Bargsten, K.,Diaz, J.F.,Marsh, M.,Cuevas, C.,Liniger, M.,Neuhaus, C.,Andreu, J.M.,Altmann, K.H.,Steinmetz, M.O. A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proc.Natl.Acad.Sci.USA, 111:13817-13821, 2014 Cited by PubMed: 25114240 DOI: 10.1073/pnas.1408124111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation