4O4H
Tubulin-Laulimalide complex
Summary for 4O4H
Entry DOI | 10.2210/pdb4o4h/pdb |
Related | 4O4I 4O4J 4O4L |
Descriptor | Tubulin alpha-1B chain, GLYCEROL, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... (12 entities in total) |
Functional Keywords | alpha-tubulin, beta-tubulin, ligase, gtpase, microtubule, stathmin, laulimalide, cell cycle, tubulin fold, cytoskeleton, cell cycle-inhibitor complex, cell cycle/inhibitor |
Biological source | Rattus norvegicus (rat) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Cytoplasm, cytoskeleton (By similarity): Q6B856 Golgi apparatus: P63043 |
Total number of polymer chains | 6 |
Total formula weight | 265009.89 |
Authors | Prota, A.E.,Bargsten, K.,Northcote, P.T.,Marsh, M.,Altmann, K.H.,Miller, J.H.,Diaz, J.F.,Steinmetz, M.O. (deposition date: 2013-12-18, release date: 2014-03-05, Last modification date: 2023-09-20) |
Primary citation | Prota, A.E.,Bargsten, K.,Northcote, P.T.,Marsh, M.,Altmann, K.H.,Miller, J.H.,Diaz, J.F.,Steinmetz, M.O. Structural basis of microtubule stabilization by laulimalide and peloruside a. Angew.Chem.Int.Ed.Engl., 53:1621-1625, 2014 Cited by PubMed: 24470331DOI: 10.1002/anie.201307749 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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