4O4L

Tubulin-Peloruside A-Epothilone A complex

Summary for 4O4L

Related4O4H 4O4I 4O4J
DescriptorTubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ... (12 entities in total)
Functional Keywordsalpha-tubulin, beta-tubulin, ligase, gtpase, microtubule, stathmin, peloruside a, epothilone a, tubulin fold, cytoskeleton, cell cycle-inhibitor complex, cell cycle/inhibitor
Biological sourceRattus norvegicus (rat)
More
Cellular locationCytoplasm, cytoskeleton P81947
Cytoplasm, cytoskeleton (By similarity) Q6B856
Golgi apparatus P63043
Total number of polymer chains6
Total molecular weight266061.41
Authors
Primary citation
Prota, A.E.,Bargsten, K.,Northcote, P.T.,Marsh, M.,Altmann, K.H.,Miller, J.H.,Diaz, J.F.,Steinmetz, M.O.
Structural basis of microtubule stabilization by laulimalide and peloruside a.
Angew.Chem.Int.Ed.Engl., 53:1621-1625, 2014
PubMed: 24470331 (PDB entries with the same primary citation)
DOI: 10.1002/anie.201307749
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.2 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22440.2%2.4%9.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution