2P5W
 
 | | Crystal structures of high affinity human T-cell receptors bound to pMHC reveal native diagonal binding geometry | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, CALCIUM ION, ... | | 著者 | Sami, M, Rizkallah, P.J, Dunn, S, Li, Y, Moysey, R, Vuidepot, A, Baston, E, Todorov, P, Molloy, P, Gao, F, Boulter, J.M, Jakobsen, B.K. | | 登録日 | 2007-03-16 | | 公開日 | 2007-09-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structures of high affinity human T-cell receptors bound to peptide major
histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
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2P5E
 | | Crystal Structures of High Affinity Human T-Cell Receptors Bound to pMHC Reveal Native Diagonal Binding Geometry | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, Cancer/testis antigen 1B, ... | | 著者 | Sami, M, Rizkallah, P.J, Dunn, S, Li, Y, Moysey, R, Vuidepot, A, Baston, E, Todorov, P, Molloy, P, Gao, F, Boulter, J.M, Jakobsen, B.K. | | 登録日 | 2007-03-15 | | 公開日 | 2007-09-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | Crystal structures of high affinity human T-cell receptors bound to peptide major
histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
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2PYF
 | | Crystal Structures of High Affinity Human T-Cell Receptors Bound to pMHC RevealNative Diagonal Binding Geometry Unbound TCR Clone 5-1 | | 分子名称: | SULFATE ION, T-Cell Receptor, Alpha Chain, ... | | 著者 | Sami, M, Rizkallah, P.J, Dunn, S, Li, Y, Moysey, R, Vuidepot, A, Baston, E, Todorov, P, Molloy, P, Gao, F, Boulter, J.M, Jakobsen, B.K. | | 登録日 | 2007-05-16 | | 公開日 | 2007-09-25 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structures of high affinity human T-cell receptors bound to peptide major
histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
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2PYE
 | | Crystal Structures of High Affinity Human T-Cell Receptors Bound to pMHC RevealNative Diagonal Binding Geometry TCR Clone C5C1 Complexed with MHC | | 分子名称: | 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, Beta-2-microglobulin, Cancer/testis antigen 1B, ... | | 著者 | Sami, M, Rizkallah, P.J, Dunn, S, Li, Y, Moysey, R, Vuidepot, A, Baston, E, Todorov, P, Molloy, P, Gao, F, Boulter, J.M, Jakobsen, B.K. | | 登録日 | 2007-05-16 | | 公開日 | 2007-09-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structures of high affinity human T-cell receptors bound to peptide major
histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
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5BS0
 | | MAGE-A3 Reactive TCR in complex with Titin Epitope in HLA-A1 | | 分子名称: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | | 著者 | Raman, M.C.C, Rizkallah, P.J, Simmons, R, Donellan, Z, Dukes, J, Bossi, G, LeProvost, G, Mahon, T, Hickman, E, Lomax, M, Oates, J, Hassan, N, Vuidepot, A, Sami, M, Cole, D.K, Jakobsen, B.K. | | 登録日 | 2015-06-01 | | 公開日 | 2016-03-02 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.
Sci Rep, 6, 2016
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5BRZ
 | | MAGE-A3 reactive TCR in complex with MAGE-A3 in HLA-A1 | | 分子名称: | Beta-2-microglobulin, GLU-VAL-ASP-PRO-ILE-GLY-HIS-LEU-TYR, HLA class I histocompatibility antigen, ... | | 著者 | Raman, M.C.C, Rizkallah, P.J, Simmons, R, Donnellan, Z, Dukes, J, Bossi, G, LeProvost, G, Mahon, T, Hickman, E, LomaX, M, Oates, J, Hassan, N, Vuidepot, A, Sami, M, Cole, D.K, Jakobsen, B.K. | | 登録日 | 2015-06-01 | | 公開日 | 2016-03-02 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.
Sci Rep, 6, 2016
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6R2L
 | | NYBR1-A2-SLSKILDTV | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, ... | | 著者 | Rizkallah, P.J, Cole, D.K, Sami, M. | | 登録日 | 2019-03-18 | | 公開日 | 2020-02-26 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | NYBR1-A2-SLSKILDTV
To Be Published
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2F54
 | | Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity | | 分子名称: | Beta-2-microglobulin, Cancer/testis antigen 1B, HLA class I histocompatibility antigen, ... | | 著者 | Rizkallah, P.J, Jakobsen, B.K, Dunn, S.M, Sami, M. | | 登録日 | 2005-11-25 | | 公開日 | 2006-04-25 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Protein Sci., 15, 2006
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2F53
 | | Directed Evolution of Human T-cell Receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without apparent cross-reactivity | | 分子名称: | Beta-2-microglobulin, Cancer/testis antigen 1B, GLYCEROL, ... | | 著者 | Rizkallah, P.J, Jakobsen, B.K, Dunn, S.M, Sami, M. | | 登録日 | 2005-11-25 | | 公開日 | 2006-04-25 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Protein Sci., 15, 2006
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2BNU
 | | Structural and kinetic basis for heightened immunogenicity of T cell vaccines | | 分子名称: | T-CELL RECEPTOR ALPHA CHAIN C REGION, T-CELL RECEPTOR BETA CHAIN C REGION | | 著者 | Chen, J.-L, Stewart-Jones, G, Bossi, G, Lissin, N.M, Wooldridge, L, Choi, E.M.L, Held, G, Dunbar, P.R, Esnouf, R.M, Sami, M, Boultier, J.M, Rizkallah, P.J, Renner, C, Sewell, A, Van Der Merwe, P.A, Jackobsen, B.K, Griffiths, G, Jones, E.Y, Cerundolo, V. | | 登録日 | 2005-04-04 | | 公開日 | 2005-05-24 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines.
J.Exp.Med., 201, 2005
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2BJS
 | | Isopenicillin N synthase C-terminal truncation mutant | | 分子名称: | FE (III) ION, ISOPENICILLIN N SYNTHETASE, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ... | | 著者 | McNeill, L.A, Sami, M, Clifton, I.J, Burzlaff, N.I. | | 登録日 | 2005-02-07 | | 公開日 | 2006-03-09 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases.
Chemistry, 23, 2017
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2BNR
 | | Structural and kinetic basis for heightened immunogenicity of T cell vaccines | | 分子名称: | BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, SYNTHETIC PEPTIDE, ... | | 著者 | Chen, J.-L, Stewart-Jones, G, Bossi, G, Lissin, N.M, Wooldridge, L, Choi, E.M.L, Held, G, Dunbar, P.R, Esnouf, R.M, Sami, M, Boultier, J.M, Rizkallah, P.J, Renner, C, Sewell, A, van der Merwe, P.A, Jackobsen, B.K, Griffiths, G, Jones, E.Y, Cerundolo, V. | | 登録日 | 2005-03-31 | | 公開日 | 2005-05-23 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines
J.Exp.Med., 201, 2005
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2BNQ
 | | Structural and kinetic basis for heightened immunogenicity of T cell vaccines | | 分子名称: | BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, SYNTHETIC PEPTIDE, ... | | 著者 | Chen, J.-L, Stewart-Jones, G, Bossi, G, Lissin, N.M, Wooldridge, L, Choi, E.M.L, Held, G, Dunbar, P.R, Esnouf, R.M, Sami, M, Boultier, J.M, Rizkallah, P.J, Renner, C, Sewell, A, van der Merwe, P.A, Jackobsen, B.K, Griffiths, G, Jones, E.Y, Cerundolo, V. | | 登録日 | 2005-03-31 | | 公開日 | 2005-05-23 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines
J.Exp.Med., 201, 2005
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6RSY
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4MNQ
 | | TCR-peptide specificity overrides affinity enhancing TCR-MHC interactions | | 分子名称: | 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ... | | 著者 | Rizkallah, P.J, Cole, D.K, Sewell, A.K, Jakobsen, B.K. | | 登録日 | 2013-09-11 | | 公開日 | 2013-11-13 | | 最終更新日 | 2017-08-02 | | 実験手法 | X-RAY DIFFRACTION (2.742 Å) | | 主引用文献 | T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.
J.Biol.Chem., 289, 2014
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6EQB
 | | HLA class I histocompatibility antigen | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL, ... | | 著者 | Rizkallah, P.J, Cole, D.K. | | 登録日 | 2017-10-12 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | TCR-induced alteration of primary MHC peptide anchor residue.
Eur.J.Immunol., 49, 2019
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6EQA
 | | HLA class I histocompatibility antigen | | 分子名称: | ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | | 著者 | Rizkallah, P.J, Cole, D.K. | | 登録日 | 2017-10-12 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (3.16 Å) | | 主引用文献 | TCR-induced alteration of primary MHC peptide anchor residue.
Eur.J.Immunol., 49, 2019
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2HP4
 | | Computational design and crystal structure of an enhanced affinity mutant human CD8-alpha-alpha co-receptor | | 分子名称: | GLYCEROL, SULFATE ION, T-cell surface glycoprotein CD8 alpha chain | | 著者 | Rizkallah, P.J, Cole, D.K, Jakobsen, B.K, Boulter, J.M, Glick, M, Gao, G.F. | | 登録日 | 2006-07-17 | | 公開日 | 2007-02-06 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor
Proteins, 67, 2007
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4JFH
 | | High Affinity alpha24-beta17 T Cell Receptor for A2 HLA-Melanoma peptide complex | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, SULFATE ION, ... | | 著者 | Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K. | | 登録日 | 2013-02-28 | | 公開日 | 2013-05-29 | | 最終更新日 | 2013-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
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4JFP
 | | A2 HLA complex with G4A heteroclitic variant of Melanoma peptide | | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, ... | | 著者 | Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K. | | 登録日 | 2013-02-28 | | 公開日 | 2013-05-29 | | 最終更新日 | 2013-07-17 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
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4JFO
 | | A2 HLA complex with E1A heteroclitic variant of Melanoma peptide | | 分子名称: | Beta-2-microglobulin, E1A heteroclitic Melanoma peptide, GLYCEROL, ... | | 著者 | Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K, Baker, B.M. | | 登録日 | 2013-02-28 | | 公開日 | 2013-05-29 | | 最終更新日 | 2013-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
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4JFD
 | | Preservation of peptide specificity during TCR-MHC contact dominated affinity enhancement of a melanoma-specific TCR | | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ... | | 著者 | Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K. | | 登録日 | 2013-02-28 | | 公開日 | 2013-05-29 | | 最終更新日 | 2013-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
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4JFF
 | | Preservation of peptide specificity during TCR-MHC contact dominated affinity enhancement of a melanoma-specific TCR | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, HLA class I histocompatibility antigen, ... | | 著者 | Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K. | | 登録日 | 2013-02-28 | | 公開日 | 2013-05-29 | | 最終更新日 | 2014-04-02 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
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4JFQ
 | | A2 HLA complex with L8A heteroclitic variant of Melanoma peptide | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-2-microglobulin, GLYCEROL, ... | | 著者 | Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K, Baker, B.M. | | 登録日 | 2013-02-28 | | 公開日 | 2013-05-29 | | 最終更新日 | 2013-07-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
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4JFE
 | | Preservation of peptide specificity during TCR-MHC contact dominated affinity enhancement of a melanoma-specific TCR | | 分子名称: | Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ... | | 著者 | Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K. | | 登録日 | 2013-02-28 | | 公開日 | 2013-05-29 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
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