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4MNQ

TCR-peptide specificity overrides affinity enhancing TCR-MHC interactions

Summary for 4MNQ
Entry DOI10.2210/pdb4mnq/pdb
DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Telomerase reverse transcriptase, ... (8 entities in total)
Functional Keywordssurface plasmon resonance (spr); biacoretm; peptide-major histocompatibility complex (pmhc): t-cell receptor (tcr), t-cells; high affinity tcr, two-step binding, adoptive therapy, immunoglobulin, adaptive immune response, immune system
Biological sourceHomo sapiens (human)
More
Cellular locationMembrane; Single-pass type I membrane protein: P01892
Secreted . Note=(Microbial infection) In the presence of M: P61769
Nucleus, nucleolus : O14746
Membrane ; Single-pass membrane protein : P01850
Total number of polymer chains5
Total formula weight94569.98
Authors
Rizkallah, P.J.,Cole, D.K.,Sewell, A.K.,Jakobsen, B.K. (deposition date: 2013-09-11, release date: 2013-11-13, Last modification date: 2017-08-02)
Primary citationCole, D.K.,Miles, K.M.,Madura, F.,Holland, C.J.,Schauenburg, A.J.,Godkin, A.J.,Bulek, A.M.,Fuller, A.,Akpovwa, H.J.,Pymm, P.G.,Liddy, N.,Sami, M.,Li, Y.,Rizkallah, P.J.,Jakobsen, B.K.,Sewell, A.K.
T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.
J.Biol.Chem., 289:628-638, 2014
Cited by
PubMed: 24196962
DOI: 10.1074/jbc.M113.522110
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.742 Å)
Structure validation

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