4MNQ

TCR-peptide specificity overrides affinity enhancing TCR-MHC interactions

Summary for 4MNQ

DescriptorHLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Telomerase reverse transcriptase, ... (8 entities in total)
Functional Keywordssurface plasmon resonance (spr); biacoretm; peptide-major histocompatibility complex (pmhc): t-cell receptor (tcr), t-cells; high affinity tcr, two-step binding, adoptive therapy, immunoglobulin, adaptive immune response, immune system
Biological sourceHomo sapiens (human)
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Cellular locationMembrane; Single-pass type I membrane protein P01892
Secreted . Note=(Microbial infection) In the presence of M P61769
Nucleus, nucleolus  O14746
Membrane ; Single-pass membrane protein  P01850
Total number of polymer chains5
Total molecular weight94569.98
Authors
Rizkallah, P.J.,Cole, D.K.,Sewell, A.K.,Jakobsen, B.K. (deposition date: 2013-09-11, release date: 2013-11-13, Last modification date: 2017-08-02)
Primary citation
Cole, D.K.,Miles, K.M.,Madura, F.,Holland, C.J.,Schauenburg, A.J.,Godkin, A.J.,Bulek, A.M.,Fuller, A.,Akpovwa, H.J.,Pymm, P.G.,Liddy, N.,Sami, M.,Li, Y.,Rizkallah, P.J.,Jakobsen, B.K.,Sewell, A.K.
T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.
J.Biol.Chem., 289:628-638, 2014
PubMed: 24196962 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M113.522110
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.742 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.285132.0%13.1%3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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