4MNQ
TCR-peptide specificity overrides affinity enhancing TCR-MHC interactions
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | HLA class I histocompatibility antigen, A-2 alpha chain | polymer | 276 | 31951.3 | 1 | UniProt (P01892) Pfam (PF00129) Pfam (PF07654) UniProt (by SIFTS) (P04439) In PDB | Homo sapiens (human) | MHC class I antigen A*2 |
| 2 | B | Beta-2-microglobulin | polymer | 100 | 11879.4 | 1 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (human) | Beta-2-microglobulin form pI 5.3 |
| 3 | C | Telomerase reverse transcriptase | polymer | 9 | 1142.4 | 1 | UniProt (O14746) In PDB | Homo sapiens | HEST2, Telomerase catalytic subunit, Telomerase-associated protein 2, TP2 |
| 4 | D | Uncharacterized protein, T-cell receptor, sp3.4 alpha chain | polymer | 200 | 22245.6 | 1 | UniProt (H2RG00) UniProt (K7N5M9) Pfam (PF07686) Pfam (PF09291) UniProt (by SIFTS) (K7N5N2) In PDB | Pan troglodytes (Chimpanzee human) | |
| 5 | E | V_segment translation product, T-cell receptor beta-1 chain C region | polymer | 240 | 27135.1 | 1 | UniProt (A0A585) UniProt (P01850) Pfam (PF07654) In PDB | Homo sapiens (human) | |
| 6 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | A, E | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 8 | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
B: 1 - 99 (UniProt: P61769)
D: 2 - 88 (UniProt: H2RG00)
D: 113 - 201 (UniProt: K7N5M9)
E: 2 - 95 (UniProt: A0A585)
E: 113 - 241 (UniProt: P01850)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | EXPRESSION TAG |
| PDB | External Database | Details |
|---|---|---|
| Asp 27 | Ala 42 | CONFLICT |
| Trp 33 | Gln 48 | CONFLICT |
| Val 89 | - | LINKER |
| Asp 90 | - | LINKER |
| Ser 91 | - | LINKER |
| Ala 92 | - | LINKER |
| Thr 93 | - | LINKER |
| Ala 94 | - | LINKER |
| Leu 95 | - | LINKER |
| Pro 96 | - | LINKER |
| Tyr 97 | - | LINKER |
| Gly 98 | - | LINKER |
| Tyr 99 | - | LINKER |
| Ile 100 | - | LINKER |
| Phe 101 | - | LINKER |
| Gly 102 | - | LINKER |
| Thr 103 | - | LINKER |
| Gly 104 | - | LINKER |
| Thr 105 | - | LINKER |
| Arg 106 | - | LINKER |
| Leu 107 | - | LINKER |
| Lys 108 | - | LINKER |
| Val 109 | - | LINKER |
| Leu 110 | - | LINKER |
| Ala 111 | - | LINKER |
| Asn 112 | - | LINKER |
E: 2 - 95 (UniProt: A0A585)
| PDB | External Database | Details |
|---|---|---|
| Ile 50 | Val 69 | CONFLICT |
| His 51 | Gly 70 | CONFLICT |
| Pro 52 | Ala 71 | CONFLICT |
| Glu 53 | Gly 72 | CONFLICT |
| Tyr 54 | Ile 73 | CONFLICT |
| Gln 96 | - | LINKER |
| Gly 97 | - | LINKER |
| Thr 98 | - | LINKER |
| Glu 99 | - | LINKER |
| Ala 100 | - | LINKER |
| Phe 101 | - | LINKER |
| Phe 102 | - | LINKER |
| Gly 103 | - | LINKER |
| Gln 104 | - | LINKER |
| Gly 105 | - | LINKER |
| Thr 106 | - | LINKER |
| Arg 107 | - | LINKER |
| Leu 108 | - | LINKER |
| Thr 109 | - | LINKER |
| Val 110 | - | LINKER |
| Val 111 | - | LINKER |
| Glu 112 | - | LINKER |
| PDB | External Database | Details |
|---|---|---|
| Tyr 148 | Phe 37 | CONFLICT |
| Cys 168 | Ser 57 | CONFLICT |
| Ala 186 | Cys 75 | CONFLICT |
| Asp 200 | Asn 89 | CONFLICT |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 94353.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 216.2 | |
| All* | Total formula weight | 94570.0 |
