1IM3
 
 | | Crystal Structure of the human cytomegalovirus protein US2 bound to the MHC class I molecule HLA-A2/tax | | 分子名称: | HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, Human T-cell lymphotropic virus type 1 Tax peptide, ... | | 著者 | Gewurz, B.E, Gaudet, R, Tortorella, D, Wang, E.W, Ploegh, H.L, Wiley, D.C. | | 登録日 | 2001-05-09 | | 公開日 | 2001-06-06 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2.
Proc.Natl.Acad.Sci.USA, 98, 2001
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1XD3
 | | Crystal structure of UCHL3-UbVME complex | | 分子名称: | MAGNESIUM ION, METHYL 4-AMINOBUTANOATE, UBC protein, ... | | 著者 | Misaghi, S, Galardy, P.J, Meester, W.J.N, Ovaa, H, Ploegh, H.L, Gaudet, R. | | 登録日 | 2004-09-03 | | 公開日 | 2004-11-23 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | Structure of the Ubiquitin Hydrolase UCH-L3 Complexed with a Suicide Substrate
J.Biol.Chem., 280, 2005
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2VE6
 | | Crystal structure of a Murine MHC class I H2-Db molecule in complex with a photocleavable peptide | | 分子名称: | BETA-2-MICROGLOBULIN, H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN D-B ALPHA CHAIN, SENDAI VIRUS EPITOPE RESIDUES 324-332 MODIFIED AT P7 | | 著者 | Grotenbreg, G.M, Roan, N.R, Guillen, E, Meijers, R, Wang, J.H, Bell, G.W, Starnbach, M.N, Ploegh, H.L. | | 登録日 | 2007-10-17 | | 公開日 | 2008-01-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Discovery of Cd8+ T Cell Epitopes in Chlamydia Trachomatis Infection Through Use of Caged Class I Mhc Tetramers.
Proc.Natl.Acad.Sci.USA, 105, 2008
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2WDT
 | | Crystal structure of Plasmodium falciparum UCHL3 in complex with the suicide inhibitor UbVME | | 分子名称: | CHLORIDE ION, UBIQUITIN, UBIQUITIN CARBOXYL-TERMINAL HYDROLASE L3 | | 著者 | Weihofen, W.A, Artavanis-Tsakonas, K, Gaudet, R, Ploegh, H.L. | | 登録日 | 2009-03-26 | | 公開日 | 2009-12-29 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Characterization and Structural Studies of the Plasmodium Falciparum Ubiquitin and Nedd8 Hydrolase Uchl3.
J.Biol.Chem., 285, 2010
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2WE6
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2J7Q
 | | Crystal structure of the ubiquitin-specific protease encoded by murine cytomegalovirus tegument protein M48 in complex with a ubquitin-based suicide substrate | | 分子名称: | GLYCEROL, MAGNESIUM ION, MCMV TEGUMENT PROTEIN M48 ENCODED UBIQUITIN- SPECIFIC PROTEASE, ... | | 著者 | Schlieker, C, Weihofen, W.A, Frijns, E, Kattenhorn, L.M, Gaudet, R, Ploegh, H.L. | | 登録日 | 2006-10-16 | | 公開日 | 2007-03-20 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes
Mol.Cell, 25, 2007
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2JX5
 | | Solution structure of the ubiquitin domain N-terminal to the S27a ribosomal subunit of Giardia lamblia | | 分子名称: | GlUb(S27a) | | 著者 | Catic, A, Sun, Z.J, Ratner, D.M, Misaghi, S, Spooner, E, Samuelson, J, Wagner, G, Ploegh, H.L. | | 登録日 | 2007-11-07 | | 公開日 | 2007-12-04 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Sequence and structure evolved separately in a ribosomal ubiquitin variant
EMBO J., 26, 2007
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5H8O
 | | Crystal structure of an ASC-binding nanobody in complex with the CARD domain of ASC | | 分子名称: | Apoptosis-associated speck-like protein containing a CARD, VHH nanobody | | 著者 | Lu, A, Schmidt, F.I, Ruan, J, Tang, C, Wu, H, Ploegh, H.L. | | 登録日 | 2015-12-23 | | 公開日 | 2016-04-06 | | 最終更新日 | 2016-05-18 | | 実験手法 | X-RAY DIFFRACTION (4.206 Å) | | 主引用文献 | A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.
J.Exp.Med., 213, 2016
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5H8D
 | | Crystal structure of an ASC binding nanobody | | 分子名称: | VHH nanobody | | 著者 | Lu, A, Schmidt, F.I, Ruan, J, Tang, C, Wu, H, Ploegh, H.L. | | 登録日 | 2015-12-23 | | 公開日 | 2016-04-06 | | 最終更新日 | 2016-05-18 | | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | | 主引用文献 | A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly.
J.Exp.Med., 213, 2016
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5TJW
 | | Influenza A virus Nucleoprotein in Complex with Inhibitory Nanobody | | 分子名称: | NP-specific inhibitory VHH, Nucleoprotein | | 著者 | Hanke, L, Knockenhauer, K.E, Ploegh, H.L, Schwartz, T.U. | | 登録日 | 2016-10-05 | | 公開日 | 2016-12-21 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.231 Å) | | 主引用文献 | The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment.
MBio, 7, 2016
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5UKB
 | | VSV N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1004 | | 分子名称: | Anti-vesicular stomatitis virus N VHH, Nucleocapsid, RNA (45-MER) | | 著者 | Hanke, L, Knockenhauer, K.E, Ploegh, H.L, Schwartz, T.U. | | 登録日 | 2017-01-20 | | 公開日 | 2017-04-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (5.473 Å) | | 主引用文献 | Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication.
EMBO Rep., 18, 2017
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5UK4
 | | VESICULAR STOMATITS VIRUS N PROTEIN IN COMPLEX WITH INHIBITORY NANOBODY 1307 | | 分子名称: | Anti-vesicular stomatitis virus N VHH, Nucleoprotein, RNA (45-MER) | | 著者 | Hanke, L, Knockenhauer, K.E, Ploegh, H.L, Schwartz, T.U. | | 登録日 | 2017-01-19 | | 公開日 | 2017-04-19 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.204 Å) | | 主引用文献 | Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication.
EMBO Rep., 18, 2017
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5FNA
 | | Cryo-EM reconstruction of caspase-1 CARD | | 分子名称: | Caspase-1 | | 著者 | Li, Y, Lu, A, Schmidt, F.I, Yin, Q, Chen, S, Fu, T.M, Tong, A.B, Ploegh, H.L, Mao, Y, Wu, H. | | 登録日 | 2015-11-11 | | 公開日 | 2016-03-30 | | 最終更新日 | 2019-09-11 | | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | | 主引用文献 | Molecular Basis of Caspase-1 Polymerization and its Inhibition by a Novel Capping Mechanism
Nat.Struct.Mol.Biol., 23, 2016
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5KTE
 | | Crystal structure of Deinococcus radiodurans MntH, an Nramp-family transition metal transporter | | 分子名称: | Divalent metal cation transporter MntH, Fab Heavy Chain, Fab Light Chain, ... | | 著者 | Bane, L.B, Gaudet, R, Weihofen, W.A, Singharoy, A. | | 登録日 | 2016-07-11 | | 公開日 | 2016-11-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.941 Å) | | 主引用文献 | Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter.
Structure, 24, 2016
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3H1D
 | | Structure of the HUWE1 HECT Domain | | 分子名称: | E3 ubiquitin-protein ligase HUWE1, SULFATE ION | | 著者 | Partridge, J.R, Schwartz, T.U. | | 登録日 | 2009-04-11 | | 公開日 | 2009-12-08 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.892 Å) | | 主引用文献 | A structural element within the HUWE1 HECT domain modulates self-ubiquitination and substrate ubiquitination activities.
J.Biol.Chem., 285, 2010
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4XT3
 | | Structure of a viral GPCR bound to human chemokine CX3CL1 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fractalkine, G-protein coupled receptor homolog US28, ... | | 著者 | Burg, J.S, Jude, K.M, Waghray, D, Garcia, K.C. | | 登録日 | 2015-01-22 | | 公開日 | 2015-03-04 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.801 Å) | | 主引用文献 | Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.
Science, 347, 2015
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4XT1
 | | Structure of a nanobody-bound viral GPCR bound to human chemokine CX3CL1 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, Fractalkine, ... | | 著者 | Burg, J.S, Jude, K.M, Waghray, D, Garcia, K.C. | | 登録日 | 2015-01-22 | | 公開日 | 2015-03-04 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.886 Å) | | 主引用文献 | Structural biology. Structural basis for chemokine recognition and activation of a viral G protein-coupled receptor.
Science, 347, 2015
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4QXW
 | | Crystal structure of the human CEACAM1 membrane distal amino terminal (N)-domain | | 分子名称: | Carcinoembryonic antigen-related cell adhesion molecule 1, MALONIC ACID, octyl beta-D-glucopyranoside | | 著者 | Huang, Y.H, Gandhi, A.K, Russell, A, Kondo, Y, Chen, Q, Petsko, G.A, Blumberg, R.S. | | 登録日 | 2014-07-22 | | 公開日 | 2014-11-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Nature, 517, 2015
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4YGA
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4TVS
 | | LAP1(aa356-583), H.sapiens, bound to VHH-BS1 | | 分子名称: | GLYCEROL, SULFATE ION, Torsin-1A-interacting protein 1, ... | | 著者 | Sosa, B.A, Schwartz, T.U. | | 登録日 | 2014-06-27 | | 公開日 | 2014-09-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | How lamina-associated polypeptide 1 (LAP1) activates Torsin.
Elife, 3, 2014
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6X08
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6X07
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6X06
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2F16
 | | Crystal structure of the yeast 20S proteasome in complex with bortezomib | | 分子名称: | N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, Proteasome component C1, Proteasome component C11, ... | | 著者 | Groll, M. | | 登録日 | 2005-11-14 | | 公開日 | 2006-03-21 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome.
Structure, 14, 2006
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5J1S
 | | TorsinA-LULL1 complex, H. sapiens, bound to VHH-BS2 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, ... | | 著者 | Demircioglu, F.E, Schwartz, T.U. | | 登録日 | 2016-03-29 | | 公開日 | 2016-08-17 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.399 Å) | | 主引用文献 | Structures of TorsinA and its disease-mutant complexed with an activator reveal the molecular basis for primary dystonia.
Elife, 5, 2016
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