Crystal structure of the yeast 20S proteasome in complex with bortezomib

Summary for 2F16

Related1RYP 1PMA
DescriptorProteasome component Y7, Proteasome component Y13, Proteasome component PRE6, ... (16 entities in total)
Functional Keywordsbeta-sandwich flanked by helices, complex structure covalently bound to the synthetic inihibtor bortezomib, hydrolase
Biological sourceSaccharomyces cerevisiae (baker's yeast)
Cellular locationCytoplasm P23639 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 P22141 P30656 P23724 P30657 P38624
Total number of polymer chains28
Total molecular weight706511.66
Groll, M. (deposition date: 2005-11-14, release date: 2006-03-21, Last modification date: 2011-07-13)
Primary citation
Groll, M.,Berkers, C.R.,Ploegh, H.L.,Ovaa, H.
Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome.
Structure, 14:451-456, 2006
PubMed: 16531229 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2005.11.019
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers22 1.0% 5.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-10-14