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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

2F16

Crystal structure of the yeast 20S proteasome in complex with bortezomib

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, OProteasome component Y7polymer25027191.82UniProt (P23639)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (baker's yeast)Macropain subunit Y7, Proteinase YSCE subunit 7, Multicatalytic endopeptidase complex subunit Y7
2B, PProteasome component Y13polymer24427050.42UniProt (P23638)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (baker's yeast)Macropain subunit Y13, Proteinase YSCE subunit 13, Multicatalytic endopeptidase complex subunit Y13
3C, QProteasome component PRE6polymer24126903.32UniProt (P40303)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (baker's yeast)Macropain subunit PRE6, Proteinase YSCE subunit PRE6, Multicatalytic endopeptidase complex subunit PRE6
4D, RProteasome component PUP2polymer24226544.82UniProt (P32379)
Pfam (PF00227)
Pfam (PF10584)
In PDB		Saccharomyces cerevisiae (baker's yeast)Macropain subunit PUP2, Proteinase YSCE subunit PUP2, Multicatalytic endopeptidase complex subunit PUP2
5E, SProteasome component PRE5polymer23325502.82UniProt (P40302)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (baker's yeast)Macropain subunit PRE5, Proteinase YSCE subunit PRE5, Multicatalytic endopeptidase complex subunit PRE5
6F, TProteasome component C1polymer24426892.52UniProt (P21242)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (baker's yeast)Macropain subunit C1, Proteinase YSCE subunit 1, Multicatalytic endopeptidase complex subunit C1
7G, UProteasome component C7-alphapolymer24327316.02UniProt (P21243)
Pfam (PF10584)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (baker's yeast)Macropain subunit C7- alpha, Proteinase YSCE subunit 7, Multicatalytic endopeptidase complex C7, Component Y8, SCL1 suppressor protein
8H, VProteasome component PUP1polymer22223987.32UniProt (P25043)
Pfam (PF00227)
Pfam (PF12465)
In PDB		Saccharomyces cerevisiae (baker's yeast)Macropain subunit PUP1, Proteinase YSCE subunit PUP1, Multicatalytic endopeptidase complex subunit PUP1
9I, WProteasome component PUP3polymer20422496.62UniProt (P25451)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (baker's yeast)Macropain subunit PUP3, Multicatalytic endopeptidase complex subunit PUP3
10J, XProteasome component C11polymer19822545.72UniProt (P22141)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (baker's yeast)Macropain subunit C11, Proteinase YSCE subunit 11, Multicatalytic endopeptidase complex subunit C11
11K, YProteasome component PRE2polymer21223325.22UniProt (P30656)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (baker's yeast)Macropain subunit PRE2, Proteinase YSCE subunit PRE2, Multicatalytic endopeptidase complex subunit PRE2
12L, ZProteasome component C5polymer22224883.92UniProt (P23724)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (baker's yeast)Multicatalytic endopeptidase complex subunit C5
13M, 1Proteasome component PRE4polymer23325945.52UniProt (P30657)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (baker's yeast)Macropain subunit PRE4, Proteinase YSCE subunit PRE4, Multicatalytic endopeptidase complex subunit PRE4
14N, 2Proteasome component PRE3polymer19621517.22UniProt (P38624)
Pfam (PF00227)
In PDB		Saccharomyces cerevisiae (baker's yeast)Macropain subunit PRE3, Proteinase YSCE subunit PRE3, Multicatalytic endopeptidase complex subunit PRE3
15H, K, N, V, Y...N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDEnon-polymer384.26Chemie (BO2)
16waterwater18.01037Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains28
Total formula weight704206.2
Non-Polymers*Number of molecules6
Total formula weight2305.4
All*Total formula weight706511.7
*Water molecules are not included.

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PDB entries from 2024-04-17

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