4QXW

Crystal structure of the human CEACAM1 membrane distal amino terminal (N)-domain

Summary for 4QXW

• Entry DOI: 10.2210/pdb4qxw/pdb
• Related: 2GK2 4QYC
• Descriptor: Carcinoembryonic antigen-related cell adhesion molecule 1, MALONIC ACID, octyl beta-D-glucopyranoside, ... (4 entities in total)
• Functional Keywords: cell adhesion
• Biological source: Homo sapiens (human)
• Cellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted. Isoform 3: Secreted. Isoform 4: Secreted. Isoform 5: Cell membrane; Single-pass type I membrane protein. Isoform 6: Cell membrane; Single-pass type I membrane protein. Isoform 7: Cell membrane; Single-pass type I membrane protein. Isoform 8: Cell membrane; Single-pass type I membrane protein: P13688
• Total number of polymer chains: 2
• Total formula weight: 24487.14

Authors

Huang, Y.H.,Gandhi, A.K.,Russell, A.,Kondo, Y.,Chen, Q.,Petsko, G.A.,Blumberg, R.S. (deposition date: 2014-07-22, release date: 2014-11-12, Last modification date: 2024-02-28)

• Primary citation: Huang, Y.H.,Zhu, C.,Kondo, Y.,Anderson, A.C.,Gandhi, A.,Russell, A.,Dougan, S.K.,Petersen, B.S.,Melum, E.,Pertel, T.,Clayton, K.L.,Raab, M.,Chen, Q.,Beauchemin, N.,Yazaki, P.J.,Pyzik, M.,Ostrowski, M.A.,Glickman, J.N.,Rudd, C.E.,Ploegh, H.L.,Franke, A.,Petsko, G.A.,Kuchroo, V.K.,Blumberg, R.S.; CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.; Nature, 517:386-390, 2015; PubMed: 25363763; DOI: 10.1038/nature13848

Experimental method

X-RAY DIFFRACTION (2.04 Å)