2J7Q

Crystal structure of the ubiquitin-specific protease encoded by murine cytomegalovirus tegument protein M48 in complex with a ubquitin-based suicide substrate

Summary for 2J7Q

Related1C3T 1D3Z 1F9J 1FXT 1G6J 1GJZ 1NBF 1OGW 1Q5W 1S1Q 1SIF 1TBE 1UBI 1UBQ 1XD3 1XQQ 1YX5 1YX6 1ZGU 2AYO 2BGF 2FCM 2FCN 2FCQ 2FCS 2FUH 2G45 2GBK 2GBM 2GBN
DescriptorMCMV TEGUMENT PROTEIN M48 ENCODED UBIQUITIN- SPECIFIC PROTEASE, M48USP, UBIQUITIN, MAGNESIUM ION, ... (8 entities in total)
Functional Keywordsherpesviridae, nuclear protein, covalent enzyme-ligand complex, deubiquitinating enzyme, hydrolase, papain-like fold, cysteine protease
Biological sourceMURINE CYTOMEGALOVIRUS
More
Total number of polymer chains4
Total molecular weight68996.69
Authors
Schlieker, C.,Weihofen, W.A.,Frijns, E.,Kattenhorn, L.M.,Gaudet, R.,Ploegh, H.L. (deposition date: 2006-10-16, release date: 2007-03-20, Last modification date: 2011-07-13)
Primary citation
Schlieker, C.,Weihofen, W.A.,Frijns, E.,Kattenhorn, L.M.,Gaudet, R.,Ploegh, H.L.
Structure of a Herpesvirus-Encoded Cysteine Protease Reveals a Unique Class of Deubiquitinating Enzymes
Mol.Cell, 25:677-, 2007
PubMed: 17349955 (PDB entries with the same primary citation)
DOI: 10.1016/J.MOLCEL.2007.01.033
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
NMR Information
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22630.2%1.3%1.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report